This product belongs to the class of thiazolidinediones oral antidiabetic drugs, and is a highly selective peroxisome proliferator-activated receptor γ (PPARγ) agonist, which controls blood sugar levels by increasing peripheral and liver insulin sensitivity. Its main mechanism of action is to activate PPARγ nuclear receptors in tissues such as fat, skeletal muscle and liver where insulin acts, thereby regulating the transcription of insulin-responsive genes and controlling the generation, transport and utilization of blood sugar.

Positive inotropic and vasodilatory effects

Stimulate the bronchial mucous glands, increase the secretion of neutral mucopolysaccharides, reduce the synthesis of acidic mucopolysaccharides and promote their metabolism, so that the physical and chemical properties of respiratory mucus tend to normal, which is conducive to excretion; stimulate the alveolar epithelial cells and Clara cells, promote the secretion of alveolar surfactant, activate the pneumocytes to synthesize surfactant, cover the entire respiratory epithelial cells, and directly protect lung function. It increases the content of phosphatidylcholine in alveolar macrophages and affects the metabolism of lung phospholipids; it activates the function of respiratory mucosal cilia, reduces the adhesion between sputum and cilia, and increases the frequency of ciliary movement by 10.8%, which is beneficial to the discharge of respiratory secretions; it has anti-inflammatory and antioxidant effects, can reduce the effects of secretory cytokines IL-1, TNF-a, and IF-Y in activated alveolar cells in bronchopulmonary lavage fluid and peripheral blood monocytes, inhibit the production of IL-1 and TNF in human monocytes in vitro, and has a significant inhibitory effect on the release of inflammatory mediators such as arachidonic acid oxidation products produced by ozone-induced airway hyperresponsiveness, can protect against lung damage caused by peroxides, including asthma, and improve the antioxidant activity of lung tissue. It is an effective anti-lipid peroxidant; it increases the concentration of antibiotics in lung tissue and its secretions; and it promotes the synthesis and secretion of gastric surfactant.

Extract from the above information

Extract from the above information