Changzhou Kangpu Pharmaceutical Co., Ltd.

Dihydropyridine calcium antagonists can selectively inhibit the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibit the release of calcium ions from cells without changing the plasma calcium ion concentration. They can simultaneously relax the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen in patients with coronary artery spasm, and relieve and prevent coronary artery spasm; they can inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption; they can relax peripheral resistance vessels, reduce peripheral resistance, and reduce systolic and diastolic blood pressure, reducing cardiac afterload; they can delay the sinus node function and atrioventricular conduction of isolated hearts, but electrophysiological studies of whole animals and humans have not found any effect of delaying atrioventricular conduction, prolonging sinus node recovery time, and slowing down sinus node rate.

It relaxes vascular smooth muscle, releases nitric oxide (NO) through metabolism to generate isosorbide mononitrate, activates guanylate cyclase, and increases cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, reducing myocardial oxygen consumption, increasing oxygen supply, and relieving angina pectoris.

It has certain anti-inflammatory, liver cell membrane protection and liver function improvement effects. It can reduce the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) caused by carbon tetrachloride, thioacetamide and D-aminogalactic acid, reduce the damage of D-aminogalactic acid to the liver and improve the chronic damage of immune factors to the liver.

It has anti-thrombotic effect. 1. It inhibits the uptake of adenosine by platelets, epithelial cells and erythrocytes, increases the local adenosine concentration, acts on the A2 receptor of platelets, stimulates adenylate cyclase, increases the cyclic adenosine monophosphate (cAMP) in platelets, and inhibits platelet aggregation; 2. It inhibits phosphodiesterase (PDE) in various tissues, and strengthens the increase in cGMP concentration caused by endothelial relaxing factor (EDRF); 3. It inhibits the formation of thromboxane A2 (TXA2), which is a strong agonist of platelet activity; 4. It enhances the effect of endogenous PGI2. Dipyridamole has a dilating effect on blood vessels.

Vitamin B1 is an important component of coenzymes required for sugar metabolism

Vitamin B2 is an important coenzyme component required for tissue respiration. Nicotinamide is a component of coenzymes I and II, and is necessary for lipid metabolism and oxidation of tissue respiration.

Vitamin B6 is a cofactor for many enzymes and is involved in the metabolism of amino acids and fats.

Nicotinamide is a component of coenzymes I and II, essential for lipid metabolism and oxidation of tissue respiration

Calcium pantothenate is a component of coenzyme A and is involved in the metabolism of sugar, fat, and protein.