Jiangsu Jibeier Pharmaceutical Co., Ltd.

Rifampicin is a semi-synthetic broad-spectrum fungicide that firmly binds to the beta subunit of DNA-dependent RNA polymerase, inhibiting the synthesis of bacterial RNA and preventing the enzyme from connecting to DNA, thereby blocking the RNA transcription process.

This product belongs to the tetracycline antibiotics. Many Rickettsia, Mycoplasma, Chlamydia, some atypical mycobacteria, and spirochetes are sensitive to this product, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to methacycline. Common clinical pathogens are seriously resistant to methacycline, including Gram-positive bacteria such as Staphylococcus and most Enterobacteriaceae. There is cross-resistance between this product and different varieties of tetracyclines.

This product can selectively inhibit the microRNA virus polymerase of infected cells. By inhibiting the RNA-dependent RNA polymerase of the virus coding in the infected cells, the synthesis of viral RNA is blocked, thereby inhibiting the virus; 50mu;g/ml can effectively inhibit various strains of human enterovirus, Coxsackievirus and poliovirus; 10mu;g/ml can inhibit acute epidemic hemorrhagic tuberculosis and keratitis.

In vitro experiments show that it has special efficacy against the following bacteria: Staphylococcus (Staphylococcus aureus, Staphylococcus epidermidis and penicillin-resistant bacteria), Streptococcus (Group A hemolytic streptococci, non-hemolytic streptococci and Streptococcus pneumoniae), Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis (indole-negative) and indole-positive Proteus, Haemophilus influenzae and Haemophilus conjunctivitis, Moraxella conjunctivitis, Acinetobacter calcoaceticus (Herellea vaginacola), Neisseria. Bacteria resistant to gentamicin are still sensitive to tobramycin. No bacteria resistant to tobramycin have been found so far, but long-term use may lead to bacterial resistance.

It binds to the ribosome 50S subunit of sensitive microorganisms, inhibits RNA-dependent protein synthesis and exerts an antibacterial effect. It has a good antibacterial effect on Gram-positive cocci such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, and has an inhibitory effect on a variety of pathogens such as Listeria, Moraxella catarrhalis, and Neisseria gonorrhoeae.

It binds to the ribosome 50S subunit of sensitive microorganisms, inhibits RNA-dependent protein synthesis and exerts an antibacterial effect. It has a good antibacterial effect on Gram-positive cocci such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, and has an inhibitory effect on a variety of pathogens such as Listeria, Moraxella catarrhalis, and Neisseria gonorrhoeae.

It binds to the ribosome 50S subunit of sensitive microorganisms, inhibits RNA-dependent protein synthesis and exerts an antibacterial effect. It has a good antibacterial effect on Gram-positive cocci such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, and has an inhibitory effect on a variety of pathogens such as Listeria, Moraxella catarrhalis, and Neisseria gonorrhoeae.

It binds to the ribosome 50S subunit of sensitive microorganisms, inhibits RNA-dependent protein synthesis and exerts an antibacterial effect. It has a good antibacterial effect on Gram-positive cocci such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, and has an inhibitory effect on a variety of pathogens such as Listeria, Moraxella catarrhalis, and Neisseria gonorrhoeae.