Jiangsu Jibeier Pharmaceutical Co., Ltd.

Vitamin K is a substance necessary for the liver to synthesize coagulation factors II, VII, IX and X. Vitamin K deficiency can cause synthesis disorders of these coagulation factors, and clinically, bleeding tendency and prolonged prothrombin time can be seen. Natural vitamin K includes K1 and K2, which are fat-soluble and their absorption depends on the normal secretion of bile. Artificially synthesized vitamin K includes K3 and K4, the former is sodium bisulfite menadione, and the latter is acetyl menadione, which are water-soluble and do not require the presence of bile for their absorption.

This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. It has a strong killing effect on Amoeba histolytica. When the concentration is 1-2μg/ml, the morphological changes can occur in 6-20 hours, and all are killed within 24 hours; when the concentration is 0.2g/ml, Amoeba histolytica can be killed within 72 hours. It has a strong killing effect on Trichomonas, and the antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Bacillus aerogenes, Eubacterium, Peptococcus and Peptostreptococcus. It has a killing effect on cells and anaerobic microorganisms growing under hypoxic conditions. The metabolites generated during reduction in the human body also have anti-anaerobic effects, inhibiting bacterial growth and reproduction by interfering with the bacterial DNA metabolism process, and ultimately leading to cell death.

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DNA gyrase inhibitors are also topoisomerase IV inhibitors. They exert their bactericidal effects by inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. They are essential in DNA replication, transcription, repair, recombination, and conversion and translocation.

Neomycin sulfate is an aminoglycoside antibiotic. This product has good antibacterial effect on Enterobacteriaceae such as Staphylococcus (methicillin-sensitive strains), Corynebacterium, Escherichia coli, Klebsiella, Proteus, etc., and has poor activity against various groups of Streptococci, Streptococcus pneumoniae, Enterococcus, etc. Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product. Bacteria have partial or complete cross-resistance to streptomycin, neomycin, kanamycin, and gentamicin. Systemic neomycin has significant nephrotoxicity and ototoxicity, so it is currently limited to oral or topical application.