Jiangsu Tasly DIYI Pharmaceutical Co., Ltd.

This product and its metabolites are cyclic adenosine monophosphate (cAMP) phosphodiesterase III inhibitors (PDEIII inhibitors), which can reduce the degradation of cAMP by inhibiting the activity of phosphodiesterase, thereby increasing the cAMP level in platelets and blood vessels, inhibiting platelet aggregation and vasodilation.

It can directly stimulate adrenaline receptors, and can also indirectly stimulate adrenaline receptors by prompting adrenaline nerve endings to release norepinephrine. It has a stimulating effect on both alpha and beta receptors. It can dilate bronchi and constrict local blood vessels, and its action time is longer; it strengthens myocardial contractility, increases cardiac output, and makes venous return to the heart sufficient; it has a stronger central nervous system stimulating effect than adrenaline.

It has ① antihistamine effect, which can compete with histamine released from tissues for H1 receptors on effector cells, thereby stopping allergic reactions; ② at the same time, it inhibits central nervous system activity and causes sedative and hypnotic effects; ③ it enhances the effect of antitussive drugs.

This product is an antibacterial drug. Escherichia coli is mostly sensitive to this product, and some strains of Enterobacteriaceae such as Enterobacter aerogenes, Enterobacter cloacae, Proteus, and Klebsiella are sensitive to this product. Aeruginosa is usually resistant to this product. This product has antibacterial effects on Gram-positive bacteria such as Enterococcus. The antibacterial activity of this product is not affected by pus and tissue decomposition products. It is more active in acidic urine. The antibacterial mechanism is to interfere with the oxidoreductase system in the bacteria, thereby blocking its metabolic process.

1. Anti-inflammatory effect: (1) Anti-allergic effect. Glycyrrhizin has anti-allergic effects such as inhibiting local allergic necrosis reaction in rabbits and inhibiting Schwartzman phenomenon. For corticosteroids, it can enhance the hormone's inhibitory effect on stress response and antagonize the hormone's anti-granulation and thymic atrophy effect. It has no effect on the exudation of hormones. (2) Inhibitory effect on arachidonic acid metabolic enzymes. Glycyrrhizin can directly bind to phospholipase A2 and lipoxygenase, selectively inhibiting the phosphorylation of these enzymes and inhibiting their activation. 2. Immunomodulatory effect: Glycyrrhizin has the following immunomodulatory effects in in vitro tests: (1) Regulatory effect on T cell activation; (2) Induction effect on interferon; (3) Activation of NK cells; (4) Promoting the differentiation of extrathymic T lymphocytes. 3. Inhibitory effect on experimental hepatocyte damage: In the primary cultured rat hepatocyte cell line in vitro, glycyrrhizin has the effect of inhibiting hepatocyte damage caused by carbon tetrachloride. 4. Inhibit virus proliferation and inactivate viruses: In the MHV infection experiment of mice, glycyrrhizin can prolong their survival days. In the vaccinia virus pox prevention experiment of rabbits, it has the effect of preventing pox; in the in vitro experiment system, it has also been observed to inhibit the proliferation of herpes viruses and the inactivation of viruses.