Centrally acting muscle relaxants that act on multiple synaptic pathways in the central nervous system to produce muscle relaxants

Centrally acting muscle relaxants act on multiple synaptic pathways in the central nervous system to produce muscle relaxant effects.

Centrally acting muscle relaxants that act on multiple synaptic pathways in the central nervous system to produce muscle relaxants

Centrally acting muscle relaxants act on multiple synaptic pathways in the central nervous system to produce muscle relaxant effects.

It relaxes vascular smooth muscle, releases nitric oxide (NO) through metabolism to generate isosorbide mononitrate, activates guanylate cyclase, and increases cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, reducing myocardial oxygen consumption, increasing coronary perfusion, and relieving angina pectoris.

It is a β-receptor agonist, which has a strong stimulatory effect on both β1 and β2 receptors, and has almost no effect on α receptors. Main effects: It acts on the cardiac β1 receptors to enhance cardiac contractility, increase heart rate, conduction, increase cardiac output and myocardial oxygen consumption. It acts on the β2 receptors of vascular smooth muscle, causing significant dilation of skeletal muscle blood vessels, and also dilation of kidney, mesenteric blood vessels and coronary arteries to varying degrees, and reducing total peripheral resistance of blood vessels. Its cardiovascular effects lead to increased systolic blood pressure, decreased diastolic blood pressure, and increased pulse pressure difference. It acts on the β2 receptors of bronchial smooth muscle to relax bronchial smooth muscle. It promotes the decomposition of glycogen and fat and increases tissue oxygen consumption.

This product is a calcium channel blocker, and its action is related to the inhibition of calcium ion influx during myocardial and vascular smooth muscle depolarization. This product can effectively dilate the epicardial and subendocardial coronary arteries, relieve spontaneous angina pectoris or angina pectoris caused by coronary artery spasm induced by ergonovine; by slowing down the heart rate and lowering blood pressure, it reduces myocardial oxygen demand, increases exercise tolerance and relieves exertional angina pectoris. This product can relax vascular smooth muscle, reduce peripheral vascular resistance, and lower blood pressure; the extent of its blood pressure reduction is related to the degree of hypertension, and only slightly reduces blood pressure in people with normal blood pressure. This product has a negative inotropic effect and can slow down the conduction of the sinoatrial node and atrioventricular node.