Anti-tumor effect: It shows high anti-tumor activity against mouse leukemia L-1210; it has a wide anti-tumor spectrum against mouse transplanted tumors, including lymphocytic leukemia L1210, granulocytic leukemia C-1498, etc.; it has a life-extending effect on mice with lymphocytic leukemia L1210 and methylcholanthrene-induced malignant glioma cells transplanted into the brain. Mechanism of action: It alkylates DNA in cells to reduce the molecular weight of DNA and inhibit DNA synthesis.

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Progesterone is a natural progestogen secreted by the corpus luteum of the ovary. It has a significant morphological effect on the endometrium stimulated by estrogen in the body and is necessary to maintain pregnancy. 1. In the late menstrual cycle, it causes the growth of glands in the uterine mucosa, uterine congestion, and endometrial thickening to prepare for the implantation of the fertilized egg. After the fertilized egg is implanted, it causes the placenta to form, reduces the excitability of the pregnant uterus, inhibits its activity, and allows the fetus to grow safely. 2. Under the combined action of estrogen, it promotes full breast development in preparation for milk production. 3. It closes the cervical opening, reduces and thickens the mucus, making it difficult for sperm to penetrate; in large doses, it inhibits the secretion of pituitary gonadotropin through negative feedback on the hypothalamus, producing an inhibitory effect on ovulation. 4. It is rapidly absorbed through the vaginal mucosa and is mainly used clinically for habitual abortion, dysmenorrhea, excessive menstrual bleeding or metrorrhagia, amenorrhea, etc. Oral high doses are also used for conditions caused by progesterone deficiency, such as premenstrual syndrome, menstrual disorders caused by cessation of ovulation, benign breast disease, premenopause and menopause, etc.

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Budesonide is a glucocorticoid with highly effective local anti-inflammatory effects. It can enhance the stability of endothelial cells, smooth muscle cells and lysosomal membranes, inhibit immune responses and reduce antibody synthesis, thereby reducing the release and activity of allergic-active mediators such as histamine, and can reduce the enzymatic process stimulated by antigen-antibody binding, inhibit the synthesis and release of bronchial contractile substances and reduce the contractile response of smooth muscles. Acute, subacute and long-term toxicity studies have found that the systemic effects of budesonide, such as weight loss, lymphoid tissue and adrenal cortex atrophy, are weaker than or comparable to other glucocorticoids. After evaluation by six different test systems, budesonide has no mutagenic effect or carcinogenic effect.