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Progesterone

Progesterone structure

CAS No:
57-83-0
Formula:
C21H30O2
Chemical Name:
Progesterone
Synonyms:
Pregn-4-ene-3,20-dione;Progesterone;Corlutin;Corlutina;Corluvite;Corporin;Corpus luteum hormone;Flavolutan;Fologenon;Gestone;Gestormone;Glanducorpin;Hormoflaveine;Hormoluton;Luteal Hormone;Luteinique;Luteodyn;Luteogan;Luteohormone;Luteosan;Luteostab;Luteovis;Lutex;Lutidon;Lutocyclin;Lutocyclin M;Lutocylin;Lutoform;Lutogyl;Lutren;Lutromone;Piaponon;Primolut;Progekan;Progesterol;Progestin;Progestone;Prolidon;Luteol;Syntolutan;Proluton;Agolutin;Lucorteum Sol;Gestron;Percutacrine Luteinique;Lipo-Lutin;Nalutron;Progestron;Luteopur;Bio-luton;Gynlutin;Gynolutone;Gesterol;Luteocrin normale;Syngestrets;Prolets;Lutin;Lutociclina;Protormone;Progestasert;Vitarrine;Δ4-Pregnene-3,20-dione;Utrogestan;Luteum;U 3672;Crinone;Progestogel;Lugesteron;Prontogest;Prometrium;Utrogest;Cyclogest;Syngesterone;Progestol;Gestiron;Lutocuclin M;Progeston;NSC 64377;NSC 9704;Progeffik;Progestan;Duraprogen;CIDR;Estima;Prochieve;Endometrin;Minagest;Microgest;Lugesterone;EAZI-BREED CIDR;4-Pregnene-3,20-dione;P4;Luteosterone;Sincrogest;Lutinus;Cue-Mate;Progeffik 200;8012-32-6;8023-13-0;257630-50-5;753497-20-0;2051138-40-8
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.

Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone Basic Attributes

Molecular Weight：

314.46200

Exact Mass：

314.46

EC Number：

200-350-6

HScode：

29372390

Characteristics

PSA：

34.14000

XLogP3：

4.72350

Appearance：

Progesterone is a white powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.

Density：

1.166 g/cm³ @ Temp: 23 °C

Melting Point：

127-131 °C

Boiling Point：

447.2ºC at 760mmHg

Flash Point：

166.7ºC

Refractive Index：

182 ° (C=2, Dioxane)

Water Solubility：

H2O: 0.00881 mg/mL at 25 °C

Storage Conditions：

Store in a cool, dry place. Store in a tightly closed container. Hormones and antibiotics room.

Vapor Pressure：

3.59X10-4 mm Hg at 25 deg C (est)

Toxicity：

LD50 intraperitoneal in rat: 327mg/kg

Specific rotation：

Specific optical rotation: +172 to +182 deg at 20 °C/D (c = 2 in dioxane)

Odor：

Odorless

PKA：

Strongest acidic: , Strongest basic: 18.92, -4.8

Safety Information

wgk germany：

hazard class code：

R40

safety instructions：

S36/37-S45

RTECS Number：

TW0175000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H350

Caution Statement：

P280

Progesterone Use and Manufacturing

Sterid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer

Computed Properties

Molecular Weight:314.5
XLogP3:3.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:314.224580195
Monoisotopic Mass:314.224580195
Topological Polar Surface Area:34.1
Heavy Atom Count:23
Complexity:589
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

58-22-0

521-18-6

53-43-0

67-66-3

7726-95-6

58-22-0

67-66-3

7726-95-6

58-22-0

Suppliers(1)

57-83-0

Suppliers(222)

5937-72-4

Material

Pyridine

Benzene

Price Analysis

Make your Progesterone purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Progesterone prices .

Drug Function and Efficacy

This product is a progestogen drug with the general effects of progesterone. In the late menstrual cycle, it can change the endometrium to the secretory phase, providing favorable conditions for the implantation of the fertilized egg. After the fertilized egg is implanted, the placenta is formed, which can reduce the excitability of the pregnant uterus and enable the fetus to grow safely. When acting together with estrogen, it can promote breast development and prepare for milk production. This product can inhibit the release of luteinizing hormone from the anterior pituitary through negative feedback to the hypothalamus, preventing the follicles from maturing and inhibiting the ovarian ovulation process.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Progesterone injection
Ingredients	Progesterone
Indication	This product can be used in combination with chemotherapy drugs to enhance their anti-cancer effects. It can also be used in combination with adrenal cortex hormones to promote thrombosis.
Specifications	1ml:10mg

Progesterone
Ingredients	Progesterone
Manufacturer	Zhejiang Xianju Junye Pharmaceutical Co., Ltd.

Progesterone injection
Ingredients	Progesterone
Indication	Occasionally, nausea, dizziness, headache, fatigue, hives, breast swelling may occur; long-term continuous use may lead to decreased menstruation or amenorrhea, abnormal liver function, edema, weight gain, etc.
Specifications	1ml:10mg
Manufacturer	Henan Kelun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

SYMBIOTEC PHARMALAB PRIVATE LTD

United States
Active
PRODUCTOS QUIMICOS NATURALES SA DE CV

United States
Active
Pharmacia & Upjohn Company LLC

Japan
Active

See More Registered Holders

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