Citrate ions react with calcium ions in the blood to form a soluble complex, calcium citrate, which is difficult to dissociate, reducing the calcium ions in the blood and inhibiting the coagulation process; at the same time, they form a buffer pair with citric acid to adjust and stabilize the pH of the solution.

It forms a buffer pair with sodium citrate to adjust and stabilize the pH of the solution; it participates in the anticoagulation mechanism.

It provides energy and osmotic pressure balance and has no direct anticoagulant effect.

Citrate ions react with calcium ions in the blood to form a soluble complex, calcium citrate, which is difficult to dissociate, reducing the calcium ions in the blood and inhibiting the coagulation process, thereby preventing blood from coagulating. Citric acid and sodium citrate form a buffer pair to adjust and stabilize the pH of the solution.

Citric acid forms a buffer pair with sodium citrate to adjust and stabilize the pH of the solution.

This product is also known as ACD-A formula. Calcium is an essential substance in the coagulation process and can promote the formation of thrombin (coagulation factor III), thrombin and fibrin, as well as activate platelets to release coagulation factor reactions. The citrate ion of this product reacts with calcium ions in the blood to form a soluble complex, calcium citrate, which is difficult to dissociate. This complex is easily soluble in water but not easy to dissociate, which reduces the calcium ions in the blood and inhibits the coagulation process, thereby preventing blood coagulation. Citric acid forms a buffer pair with sodium citrate to adjust and stabilize the pH of the solution. Sodium citrate is generally completely oxidized and metabolized in the tricarboxylic acid cycle, and its oxidation rate is close to the normal transfusion rate. The toxic dose of sodium citrate for healthy adults is about 15g, which is equivalent to 4000~5000ml of sodium citrate anticoagulant blood.