Trisodium citrate dihydrate
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Trisodium citrate dihydrate
structure -
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CAS No:
6132-04-3
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Formula:
C6H9Na3O9
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Chemical Name:
Trisodium citrate dihydrate
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Synonyms:
ANTI-BABOON IGM, BIOTIN;BETA-HYDROXY-TRICARBOXYLIC ACID MONOHYDRATE;HYDROXYTRICARBALLYLIC ACID MONOHYDRATE;CITRIC ACID NA3-SALT 2H2O;CITRIC ACID H2O;CITRIC ACID TRISODIUM SALT DIHYDRATE;CITRIC ACID, 3NA, DIHYDRATE;CITRIC ACID-1-HYDRATE
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CAS No:
Description
Sodium citrate dehydrate is an anticoagulant and also used as a buffer and food preservatives.
PelletsLargeCrystals|WHITE SOLID IN VARIOUS FORMS.
Sodium citrate dihydrate is the dihydrate of trisodium citrate. It has a role as an anticoagulant. It contains a sodium citrate.|Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.
It is colorless crystals or white crystalline powder, and is odorless, cool and salty. It has no melting point with a relative density of 1.857. It is stable in air at room temperature with loss of crystal water when being heated to 150 °C loss of crystal water; further heating will cause its decomposition. It is insoluble in ethanol but highly soluble in water. 5% aqueous solution has a pH value of 7.6 to 8.6. Rats by intraperitoneal injection: LD50: 1549 mg/kg; ADI without any special provisions (FAOWHO, 1994).
white powder or colourless crystals
Trisodium citrate dihydrate Basic Attributes
294.1
293.99400
6104939
612-118-5
B22547B95K
1219
Yes
DTXSID1049437
white
2918 15 00
Characteristics
λ: 260 nm Amax: 0.01λ: 280 nm Amax: 0.01
159.08000
-5.38120
PelletsLargeCrystals
1.76
>300 °C(lit.)
309.6ºC at 760 mmHg
155.2ºC
1.58
720 g/L (25 ºC)
Store at RT.
LD50 orally in Rabbit: > 8000 mg/kg
Odorless
7.0-9.0 (25℃, 50mg/mL in H2O)
6.40
129 Ų [M-H]-
Store at +5°C to +30°C.
Safety Information
NONH for all modes of transport
1
Xi
26-36/37/39-24/25-36
GE7810000
Xi
Sodium citrate dihydrate is a stable material. Aqueous solutions may be sterilized by autoclaving. On storage, aqueous solutions may cause the separation of small, solid particles from glass containers.The bulk material should be stored in an airtight container in a cool, dry place.
Stable. Incompatible with bases, reducing agents, oxidizing agents.
P264, P280, P305+P351+P338, P33, P313
37/38-41-36/37/38
Aqueous solutions are slightly alkaline and will react with acidic substances. Alkaloidal salts may be precipitated from their aqueous or hydro-alcohol solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Other incompatibilities include bases, reducing agents, and oxidizing agents.
Combustible.
Not Classified
Use water spray, powder.
Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.
The substance is irritating to the eyes and respiratory tract.
NO open flames.
Use ventilation (not if powder).
Wear safety spectacles.
Drug Information
A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. (See all compounds classified as Buffers.)|Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)|Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods. (See all compounds classified as Food Preservatives.)
Fresh air, rest.
Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
anhydrous sodium citrate
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Cough. Sore throat.
Redness.
Trisodium citrate dihydrate Use and Manufacturing
Trisodium citrate has the chemical formula of Na3C6H5O7. It is sometimes referred to simply as sodium citrate, though sodium citrate can refer to any of the three sodium salts of citric acid. It possesses a saline, mildly tart flavor. It is mildly basic and can be used along with citric acid to make biologically compatible buffers.
Agricultural chemicals (non-pesticidal)
Agricultural products (non-pesticidal)
It can be used as Ph adjusting agents and emulsifying enhancers applied to jam, candy, jelly and ice cream; its combination with citric acid has an effect of alleviating tour; it also has effects on forming complex with metal ions. China rules that it can be applied to various types of food with appropriate usage according to the absolute necessity.It can be used as a food additive, as complex agent and buffering agent in electroplating industry; at the field of pharmaceutical industry, it is used for the manufacturing of anti-clotting drugs; and used as the detergent additives in light industry.It is used as the analysis agents used for chromatography analysis and can also used for preparing bacterial culture medium; moreover, it can also be applied into pharmaceutical industry.The product can be used for the flavoring processing of food, as stabilizers, buffers and deputy complex-forming agents in non-toxic electroplating industry; at pharmaceutical industry, it is used as anti-clotting agent, phlegm drugs and diuretics drugs. It can also be used in brewing, injection, newspaper and movies medicines.
Sodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.
Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.
All other basic organic chemical manufacturing
EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Computed Properties
Molecular Weight:294.10
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:293.99396471
Monoisotopic Mass:293.99396471
Topological Polar Surface Area:143
Heavy Atom Count:18
Complexity:211
Covalently-Bonded Unit Count:6
Compound Is Canonicalized:Yes
Price Analysis
Drug Function and Efficacy
Citrate ions react with calcium ions in the blood to form a soluble complex, calcium citrate, which is difficult to dissociate and inhibits the coagulation process; it forms a buffer pair with citric acid to regulate and stabilize the pH of the solution; and it is completely oxidized and metabolized in the tricarboxylic acid cycle.
Registered Holders
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ANMOL CHEMICALS PRIVATE LTD
Active
United States
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INDIA PHOSPHATE AND ALLIED INDUSTRIES PRIVATE LTD
Active
United States
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MACCO ORGANIQUES SRO
Active
United States
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