Shanxi Taiyuan Pharmaceutical Co., Ltd.

It selectively inhibits the action of dihydrofolate reductase. When used in combination with sulfamethoxazole, it can double-block the bacterial folate metabolism. The synergistic antibacterial effect is stronger than that of a single drug, and the number of strains that are resistant to it is reduced.

It acts on dihydrofolate synthase, interfering with the first step of folic acid synthesis. When used in combination with trimethoprim, it can doubly block the bacterial folic acid metabolism. The synergistic antibacterial effect is stronger than that of a single drug, and the number of strains resistant to it is reduced.

This product is a macrolide antibiotic, and its mechanism of action and antibacterial spectrum are similar to those of erythromycin, but it has a stronger antibacterial effect on Gram-positive bacteria, and is effective against Staphylococcus, hemolytic Streptococcus, Pneumococcus, Diphtheria Corynebacterium, Tetanus Corynebacterium, and Anthrax Corynebacterium. It also has antibacterial effects on Gram-negative bacteria such as gonococci and pertussis Bordetella. Some erythromycin-resistant Staphylococcus aureus are still sensitive to kitasamycin, and it is also quite active against Leptospira, Rickettsia, and Mycoplasma.

Piperazine has the effect of paralyzing the muscles of roundworms. Its mechanism may be that piperazine exerts an anticholinergic effect at the neuromuscular junction of the worm body, blocks the excitatory effect of acetylcholine on the muscles of roundworms, or changes the permeability of the muscle cell membrane of the worm body to ions, affecting the transmission of nerve impulses; it can also inhibit the production of succinate, reduce the supply of energy, block the neuromuscular junction, and prevent the impulse from being delivered. As a result, the roundworms are detached from the parasitic site and excreted from the body with intestinal peristalsis. Ascaris does not show excitatory effects before paralysis, so it is safer to use this product. This product has no effect on roundworm larvae, and its effect on the muscles of mammals is also very weak. Its mechanism of action on pinworms is not yet clear.

It has local analgesic effect and antiseptic effect

This product is a broad-spectrum antibacterial agent, with bactericidal effect at high concentrations. It has antibacterial effects on Streptococcus pneumoniae, hemolytic Streptococcus, Streptococcus viridans and some Staphylococci, Clostridium perfringens, Bacillus anthracis, Yersinia pestis, Corynebacterium diphtheriae, Clostridium tetani, Brucella, Haemophilus influenzae, Campylobacter, Vibrio cholerae, etc. It also has inhibitory effects on Rickettsia, Mycoplasma, Chlamydia, Spirochete, and some protozoa. This product has better effects on Gram-positive bacteria than Gram-negative bacteria, but Enterococcus is resistant to it. The mechanism of action is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, preventing the connection of aminoacyl-tRNA at this position, thereby inhibiting the growth of peptide chains and affecting the synthesis of bacterial proteins.