It is converted into flavine mononucleotide (FMN) and flavin adenine dinucleotide, both of which are important coenzymes for tissue respiration. It can also activate vitamin B6, promote the conversion of tryptophan into niacin, and may be related to maintaining the integrity of red blood cells.

Participates in the tissue respiration process and acts as a coenzyme.

Vitamin B2 is converted into flavin mononucleotide (FMN) and flavin adenine dinucleotide, both of which are important coenzymes for tissue respiration. It can also activate vitamin B6 and convert amino acids into niacin, and may be related to maintaining the integrity of red blood cells.

Vitamin B2 is converted into flavin mononucleotide (FMN) and flavin adenine dinucleotide, both of which are important coenzymes for tissue respiration. It can also activate vitamin B6 and convert amino acids into niacin, and may be related to maintaining the integrity of red blood cells.

Vitamin B2 is converted into flavin mononucleotide (FMN) and flavin adenine dinucleotide, both of which are important coenzymes for tissue respiration. It can also activate vitamin B6 and convert amino acids into niacin, and may be related to maintaining the integrity of red blood cells.

1. Effects on water and electrolyte excretion: diuretic effect, increased excretion of urinary sodium, potassium, chloride, phosphorus and magnesium, and decreased excretion of urinary calcium; inhibiting the reabsorption of sodium chloride in the distal tubule proximal and proximal tubules, increasing Na-K exchange in the distal tubules and collecting ducts, and increasing K secretion. 2. Antihypertensive effect: In addition to diuresis and sodium excretion, there may be extrarenal mechanisms involved in blood pressure reduction. 3. Effects on renal hemodynamics and glomerular filtration function: reduced reabsorption of water and Na by the renal tubules, increased intra-tubular pressure, stimulation of the macula densa through tubule-glomerular reflex, increased secretion of renin and angiotensin in the kidney, causing renal vasoconstriction, decreased renal blood flow, contraction of the glomerular afferent and efferent arterioles, and decreased glomerular filtration rate.

1. Effects on water and electrolyte excretion: diuretic effect, increase urinary sodium, potassium, chloride, phosphorus and magnesium ion excretion, reduce urinary calcium excretion; inhibit the reabsorption of sodium chloride in the distal tubule and the proximal tubule, increase Na-K exchange, and increase K secretion. It may work by inhibiting the activity of carbonic anhydrase and phosphodiesterase. 2. Antihypertensive effect: In addition to diuresis and sodium excretion, it may also involve extrarenal mechanisms such as increased gastrointestinal excretion of Na. 3. Effects on renal hemodynamics and glomerular filtration function: reduce tubular reabsorption of water and Na, increase intratubular pressure, stimulate the macula densa to increase the secretion of renin and angiotensin through tubular-glomerular reflex, lead to renal vasoconstriction, and decrease renal blood flow and glomerular filtration rate.

Trimethoprim (TMP) is an antibacterial agent, a lipophilic weak base, and its chemical structure belongs to the pyrimethamine class. It has antibacterial activity against Escherichia coli, Klebsiella, Proteus mirabilis, Salmonella, and Shigella, but has no obvious antibacterial effect on Streptococcus pneumoniae, Neisseria gonorrhoeae, and Neisseria meningitidis, and has no effect on Pseudomonas aeruginosa. The mechanism of action of this product is to interfere with bacterial folic acid metabolism. It mainly selectively inhibits the activity of bacterial dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, and synthetic folic acid is the main component of nucleic acid biosynthesis. Therefore, this product prevents the synthesis of bacterial nucleic acids and proteins, and the binding of this product to bacterial dihydrofolate reductase is 50,000 to 60,000 times tighter than that to mammalian enzymes. The combination of this product and sulfonamides can double block the bacterial folic acid synthesis metabolism, have a synergistic effect, enhance the antibacterial activity of sulfonamides, and convert the antibacterial effect into a bactericidal effect, reducing the production of drug-resistant strains.

Vitamin B1 is an important component of coenzymes required for sugar metabolism

Vitamin B2 is an important coenzyme component required for tissue respiration. Nicotinamide is a component of coenzymes I and II, and is necessary for lipid metabolism and oxidation of tissue respiration.

Vitamin B6 is a cofactor for many enzymes and is involved in the metabolism of amino acids and fats.

Nicotinamide is a component of coenzymes I and II, essential for lipid metabolism and oxidation of tissue respiration

Calcium pantothenate is a component of coenzyme A and is involved in the metabolism of sugar, fat, and protein.