Hebei Meitu Pharmaceutical Co., Ltd.

It acts on dihydrofolate synthase, interferes with the synthesis of folate reductase, and can be used in conjunction with trimethoprim to double-block bacterial folate metabolism and enhance antibacterial effects.

It acts on dihydrofolate synthase, interferes with the synthesis of folate reductase, and can be used in conjunction with trimethoprim to double-block bacterial folate metabolism and enhance antibacterial effects.

Interfere with the function of synthetic folate reductase. When used in conjunction with sulfonamides, it can double block bacterial folate metabolism and enhance antibacterial effect.

Dopamine 2 (D2) receptor antagonist, 5-hydroxytryptamine 4 (5-HT4) receptor agonist, mildly inhibits 5-HT3 receptors; has a strong central antiemetic effect, inhibits prolactin inhibitory factor and promotes prolactin secretion, has a weak sedative effect, promotes gastric and upper intestinal motility, increases gastrointestinal sphincter tension, and increases lower esophageal sphincter pressure.

It inhibits the synthesis and release of prostaglandins in the hypothalamus, restores the normal responsiveness of the sensory neurons in the temperature regulation center, and has an antipyretic effect; it has an analgesic effect by inhibiting the synthesis of prostaglandins, etc.; it inhibits the synthesis and release of prostaglandins in the local tissue of inflammation, stabilizes lysosomal enzymes, and affects the phagocytic function of phagocytes, thus playing an anti-inflammatory role

It is a peripheral analgesic. It inhibits the synthesis and release of prostaglandins (PGE1) in the hypothalamic temperature regulation center, causing peripheral vasodilation and sweating to achieve an antipyretic effect. At the same time, it can inhibit the effects of PGE1, bradykinin and histamine, increase the pain threshold and produce analgesic effect.

It is a central nervous system stimulant that can excite the cerebral cortex, increase sensitivity to the outside world, and constrict cerebral blood vessels, thus enhancing the headache relief effects of the first two drugs.

It has a strong histamine H1 receptor blocking effect, can alleviate other respiratory symptoms caused by allergies, and also has a mild inhibitory effect on the central nervous system

This product and its metabolites can cross-link with nucleic acids through alkylation, and may also produce anti-cancer effects by changing proteins. It can interact with DNA polymerase in the body and has effects on all stages of proliferative cells. It is teratogenic to rabbits and mice.

Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, and the serum potassium concentration is only 3.5-5.0 mmol/L. The body mainly relies on Na+-K+ ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H+ enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc.