Jilin Huinan Changlong BLO-CHEMICAL Pharmaceutcal Co., Ltd.

This product is an anticoagulant that can affect many aspects of the coagulation process. By combining with antithrombin III (AT-III) to form a complex, it accelerates the inactivation of AT-III on coagulation factors, thereby inhibiting the formation of thrombin prokinase and counteracting the effect of the formed thrombin prokinase. It can inhibit the adhesion and aggregation of platelets, prevent platelet disintegration and release platelet factor 3 and 5-hydroxytryptamine. The anticoagulant effect of heparin calcium is related to the strong negatively charged sulfate group in its molecule. If the sulfate group is hydrolyzed or neutralized by protamine with a strong positive charge, it will quickly lose its anticoagulant activity. Recent studies have found that heparin calcium also has a variety of non-anticoagulant pharmacological effects such as regulating blood lipids, anti-inflammation, anti-complement, anti-allergy, and immune regulation.

This product is a selective 5-HT3 receptor antagonist. Its mechanism of action may be to antagonize the 5-HT3 receptors in the peripheral vagus nerve endings and central chemoreceptor areas, thereby blocking the vomiting reflex caused by factors such as chemotherapy and surgery that promote the release of 5-HT from intestinal chromaffin cells and excite the vagus afferent nerves. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.

This product is a first-generation cephalosporin, which has good antibacterial effect on some strains of Gram-positive cocci such as non-penicillinase-producing and penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococci, group A hemolytic streptococci, Streptococcus pneumoniae and viridans streptococci. Anaerobic Gram-positive bacteria are mostly sensitive to this product, while Bacteroides fragilis is resistant to it. Methicillin-resistant Staphylococci and Enterococci are resistant to this product. The effect of this product on Gram-positive and Gram-negative bacteria is similar to that of cephalexin. This product has a certain effect on gonococci and is also active against enzyme-producing gonococci; its activity against Haemophilus influenzae is poor.

This product is a first-generation cephalosporin, which has good antibacterial effect on some strains of Gram-positive cocci such as non-penicillinase-producing and penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococci, group A hemolytic streptococci, Streptococcus pneumoniae and viridans streptococci. Anaerobic Gram-positive bacteria are mostly sensitive to this product, while Bacteroides fragilis is resistant to it. Methicillin-resistant Staphylococci and Enterococci are resistant to this product. The effect of this product on Gram-positive and Gram-negative bacteria is similar to that of cephalexin. This product has a certain effect on gonococci and is also active against enzyme-producing gonococci; its activity against Haemophilus influenzae is poor.

It has a direct relaxant effect on the smooth muscles of the respiratory tract, part of which is due to the release of endogenous adrenaline and norepinephrine. As a purine receptor blocker, it can counteract the contractile effect of adenine and other substances on the respiratory tract. It can enhance the contractility of the diaphragm and improve respiratory function.

It can directly stimulate adrenaline receptors and indirectly stimulate receptors by promoting the release of norepinephrine from adrenergic nerve endings. It has a stimulating effect on both alpha and beta receptors. It can dilate bronchi and constrict local blood vessels to eliminate congestion and swelling of the nasopharyngeal mucosa and relieve symptoms of nasal congestion. It can strengthen myocardial contractility and increase cardiac output. It has a stronger central nervous system stimulating effect than adrenaline.

Theophylline has a direct relaxant effect on the smooth muscle of the respiratory tract, and its effect is partly due to the release of endogenous adrenaline and norepinephrine. In addition, theophylline is a purine receptor blocker, which can counteract the contraction of adenine and other substances on the respiratory tract. Theophylline can enhance the contraction of the diaphragm, especially when the diaphragm is weak, so it is beneficial to improve respiratory function. Methylephedrine hydrochloride can directly stimulate adrenaline receptors, and can also indirectly stimulate adrenaline receptors by prompting adrenergic nerve endings to release norepinephrine, and has an stimulating effect on both alpha and beta receptors. It can dilate the bronchi and contract local blood vessels to eliminate congestion and swelling of the nasopharyngeal mucosa, relieve nasal congestion symptoms, and has a longer duration of action; strengthen myocardial contractility, increase cardiac output, and make venous return to the heart sufficient; it has a stronger central nervous system excitation effect than adrenaline.