STAR Pharmaceutical Pte.ltd

It has high antibacterial activity against most aerobic Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae and Oxytobacter, aerogenes, Cloacae, Proteus, Serratia, Citrobacter, Shigella and other Enterobacteriaceae, as well as influenza bacilli, gonococci, meningococci, etc. It also has good antibacterial effect against Pseudomonas aeruginosa, but has poor antibacterial effect against some Pseudomonas and Acinetobacter species other than Pseudomonas aeruginosa, and has no antibacterial activity against aerobic Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as anaerobic bacteria. Aztreonam exerts its bactericidal effect by binding to penicillin-binding protein 3 (PBP3) on the cell membrane of sensitive aerobic Gram-negative bacteria and inhibiting the synthesis of bacterial cell walls.

It has a broad spectrum of antibacterial activity against Gram-positive and Gram-negative bacteria, especially against Escherichia coli, Klebsiella, Haemophilus influenzae, Proteus and Bacteroides fragilis. Its mechanism of action is that it shows a strong affinity for penicillin-binding protein, which is the usual point of action of β-lactam antibiotics, inhibits cell wall synthesis, binds to peptidoglycan, inhibits the binding of peptidoglycan to lipoprotein to promote bacteriolysis, and shows a strong bactericidal effect in a short time. This product shows antibacterial effect on bacteria during the proliferation period and the early stage of the stable period, and has a bactericidal effect at concentrations lower than the MIC, and lyses bacteria in a short time. The antibacterial effect in vivo is stronger than the prediction of the MIC.

The first generation of cephalosporins has a broad antibacterial spectrum and strong activity against Gram-positive bacteria. It is sensitive to penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococcus, Streptococcus pyogenes, Streptococcus pneumoniae, group B hemolytic Streptococcus, viridans Streptococcus, Staphylococcus epidermidis, Corynebacterium diphtheriae, and Bacillus anthracis. Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Neisseria gonorrhoeae are highly sensitive. Some strains of Escherichia coli, Klebsiella, Salmonella, Shigella, and Proteus are moderately sensitive, and most of the other Gram-negative rods are resistant. Gram-positive anaerobic bacteria are sensitive, and Bacteroides fragilis is resistant. It mainly inhibits the synthesis of bacterial cell walls.

The first generation of cephalosporins has a broad antibacterial spectrum and strong activity against Gram-positive bacteria. It is sensitive to penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, group B hemolytic Streptococcus, viridans streptococci, Staphylococcus epidermidis, Corynebacterium diphtheriae, and Bacillus anthracis. Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Neisseria gonorrhoeae are highly sensitive, and some strains of Escherichia coli, Klebsiella, Salmonella, Shigella, and Proteus are moderately sensitive. Gram-positive anaerobic bacteria are sensitive, and Bacteroides fragilis is resistant. It mainly inhibits the synthesis of bacterial cell walls.

First-generation cephalosporins have a broad antibacterial spectrum and are highly active against gram-positive bacteria. They are sensitive to penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, group B hemolytic Streptococci, viridans streptococci, Staphylococcus epidermidis, Corynebacterium diphtheriae, and Bacillus anthracis; highly sensitive to Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Neisseria gonorrhoeae; moderately sensitive to some strains of Escherichia coli, Klebsiella, Salmonella, Shigella, and Proteus; sensitive to gram-positive anaerobic bacteria, and resistant to Bacteroides fragilis. They mainly inhibit the synthesis of bacterial cell walls.