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Cephalothin sodium

Cephalothin sodium structure

CAS No:
58-71-9
Formula:
C16H16N2O6S2.Na
Chemical Name:
Cephalothin sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-,sodium salt (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-(hydroxymethyl)-8-oxo-7-[2-(2-thienyl)acetamido]-,acetate (ester),monosodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt,(6R-trans)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-,monosodium salt,(6R,7R)-;38253;Cephalothin sodium;Sodium cephalothin;Sodium cephalotin;Sodium 3-acetoxymethyl-7β-(2-thienylacetamido)ceph-3-em-4-carboxylate;Sodium 7-(2-thienylacetamido)-3-acetoxymethyl-3-cephem-4-carboxylate;Sodium (thienylacetamido)cephalosporanate;Sodium 7-[2-(2-thienyl)acetamido]cephalosporanate;Keflin;Lilly 38253;Microtin;Cefalothine sodium;Cefalothin sodium;Cepovenin;Ceporacin;Seffin;Cephalothin sodium salt;Sodium cefalotin;Synclotin;Cephation;Lospoven;Coaxin;Averon 1;Toricelocin;Cemastin;115699-56-4;63-60-5;11048-05-8;53493-25-7;297760-78-2
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cephalothin sodium is a first generation cephem antibiotic with a wide range antibacterial activity, is active against gram-positive and gram-negative bacteria.

Cephalothin sodium Basic Attributes

Molecular Weight：

418.42

Exact Mass：

418.026917

EC Number：

200-394-6

HScode：

29419000

Characteristics

PSA：

169

XLogP3：

-0.41360

Appearance：

Odour

Melting Point：

204.5 °C

Boiling Point：

757.2°C at 760 mmHg

Flash Point：

411.8ºC

Water Solubility：

H2O: 50 mg/mL, clear, faintly yellow

Storage Conditions：

2-8°C

Vapor Pressure：

1.7X10-14 mm Hg at 25 deg C (est)

Toxicity：

Oral-Rat LD50: >10000 mg/kg; Oral-Mouse LD: > 10000 mg/kg

Flammability characteristics：

Combustible, the fire emits nitrogen oxides, sulfur oxides and sodium oxide to stimulate the smoke spicy

Specific rotation：

D +135° (c = 1.0 in water)

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

42/43

safety instructions：

22-36/37

RTECS Number：

XI0388300

Marks：

Xn,Xi

Storage features：

Warehouse low temperature, ventilated, dry

Stability/Shelf Life：

Solutions of cephalothin may darken, especially if stored at room temperature. A slight discoloration does not affect potency. Solutions stored under refrigeration may precipitate, but the precipitate can be redissolved by warming to room temperature with constant agitation.

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334

Toxicity

Toxicity class：

practically nontoxic

Cephalothin sodium Use and Manufacturing

Methods of Manufacturing

Using fermented cephalosporin C as the raw material, 7-amino cephalosporanic acid (7-ACA) is condensed with thiophene acetyl chloride by protective hydrolysis. The resulting product is extracted with butyl acetate, activated carbon is decolorized, and finally methanol sodium acetate is added Salt formation, crystallization and cefotaxime sodium.

Uses

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics,strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics,and for immunology studies in relation to antibiotics.It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Material

Butyl acetate

Sodium acetate trihydrate

7-Aminocephalosporanic acid

Drug Function and Efficacy

First-generation cephalosporin with a broad antibacterial spectrum and strong activity against Gram-positive bacteria; sensitive to penicillinase-producing and non-producing Staphylococcus aureus, coagulase-negative Staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, group B hemolytic Streptococcus, viridans streptococci, Staphylococcus epidermidis, Corynebacterium diphtheriae, and Bacillus anthracis; highly sensitive to Haemophilus influenzae, Neisseria meningitidis, Moraxella catarrhalis, and Neisseria gonorrhoeae; moderately sensitive to some strains of Escherichia coli, Klebsiella, Salmonella, Shigella, and Proteus; sensitive to Gram-positive anaerobic bacteria, resistant to Bacteroides fragilis; inhibits bacterial cell wall synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ceftriaxone Sodium for Injection
Ingredients	The main ingredient of this product is ceftriaxone sodium, and its chemical name is (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-thienyl)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt.
Indication	1. It is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, diphenhydramine hydrochloride and other antihistamines, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. It may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone sodium succinate, phenytoin sodium, prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. 2. The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. 3. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of β-lactamase.
Specifications	0.5g
Manufacturer	Anhui Pioneer Pharmaceutical Co., Ltd.

Ceftriaxone Sodium for Injection
Ingredients	The main ingredient of this product is ceftriaxone sodium, and its chemical name is (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-thienyl)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt.
Indication	1. It is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, diphenhydramine hydrochloride and other antihistamines, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. It may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone sodium succinate, phenytoin sodium, prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. 2. The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. 3. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of β-lactamase.
Specifications	3.0g
Manufacturer	Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

Ceftriaxone Sodium for Injection
Ingredients	The main ingredient of this product is ceftriaxone sodium, and its chemical name is (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-thienyl)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt.
Indication	1. It is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium gluconate, diphenhydramine hydrochloride and other antihistamines, lidocaine, norepinephrine, metahydroxylamine, methylphenidate, succinylcholine, etc. It may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone sodium succinate, phenytoin sodium, prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. 2. The combined use of strong diuretics such as furosemide, ethacrynic acid, bumetanide, anti-tumor drugs such as carmustine, streptozocin, and aminoglycoside antibiotics with this product may increase nephrotoxicity. 3. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to it due to the production of β-lactamase.
Specifications	Calculated as C16H16N2O6S2 1.5g

See More Related Drugs

Registered Holders

ANTIBIOTICOS DO BRASIL LTDA.

Brazil
Active
China UNION Chempharma (SUZHOU) Co., Ltd.

China
Active
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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