Not clearly described

This product can reduce the level of DHBV-DNA in the serum of ducks infected with duck hepatitis B virus (DHBV); it has a protective effect on toxic liver damage in mice caused by CCl4 and D-galactosamine.

In the carbon tetrachloride model, it can reduce the serum transaminase and hydroxyproline content in the liver of animals, reduce the degree of liver lesions and reduce the level of DHBV-DNA in the serum of ducks infected with hepatitis B virus (HBV). In vitro experiments show that it can inhibit the proliferation of mouse skin fibroblasts (NIH/3T3 cells) and the synthesis of extracellular matrix; it can inhibit the proliferation and synthesis of extracellular matrix of rat hepatic stellate cells and promote their apoptosis. In the rat liver fibrosis model induced by carbon tetrachloride, dimethylnitrosamine and galactosamine, after oral administration of matrine for prevention and treatment, the serum transaminase, extracellular matrix (hyaluronic acid, laminin, type III collagen and type IV collagen) content of animals, as well as liver cell degeneration, necrosis, inflammatory activity and fibrosis in liver tissue were significantly improved.

This product is an aminoglycoside antibiotic that has good antibacterial effects on various Gram-negative and Gram-positive bacteria. The mechanism of action is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly.