This product is a hydroxyl compound. Its quaternary ammonium group can tend to the cationic site of the phosphorylated cholinesterase that has lost its activity and is combined with the organophosphorus insecticide. Its nucleophilic group can directly combine with the phosphorylated group of cholinesterase and then detach from the cholinesterase together, so that the cholinesterase returns to its original state and regains its activity. It has no resurrection effect on the cholinesterase inhibited by chronic organophosphorus insecticide poisoning. This product has a significant effect on the nicotine-like symptoms caused by organophosphorus insecticides, but a weak effect on the phytosterol-like symptoms, and no significant effect on the symptoms of the central nervous system.

This product belongs to Class III antiarrhythmic drugs. The main electrophysiological effect is to prolong the action potential and effective refractory period of various myocardial tissues, which is conducive to eliminating reentrant excitement. At the same time, it has mild non-competitive α and β adrenergic receptor blocking and mild Class I and IV antiarrhythmic properties. Reduce the automaticity of the sinus node. It has no effect on the resting membrane potential and action potential height. The inhibition of forward conduction of the atrioventricular bypass pathway is greater than the reverse. Due to excessive prolongation of repolarization, the electrocardiogram after oral administration has a prolonged QT interval and T wave changes, which can slow down the heart rate by 15~20% and prolong the PR and Q-T intervals by about 10%. It has a direct dilation effect on the coronary arteries and peripheral blood vessels. It can affect thyroid hormone metabolism.

Extract from the above information

Extract from the above information

This product mainly acts on α receptors, directly stimulating α receptors. Its effect is weaker than that of norepinephrine but more persistent. Its cardiovascular effect is similar to that of norepinephrine. It can constrict blood vessels, continuously increase systolic and diastolic blood pressure, and enhance myocardial contractility. The cardiac output of normal people does not change much, but it can increase the cardiac output of patients with shock. The excitement of heart rate is not very significant, rarely causes arrhythmia, and has no central nervous system excitation effect. Because its pressor effect is reliable and lasts for a long time, it rarely causes reactions such as palpitations or decreased urine volume. When administered continuously, because this product indirectly replaces the transmitter in the adrenergic nerve vesicles, it can reduce the transmitter and weaken the intrinsic effect. Therefore, it cannot be stopped suddenly to avoid rebound hypotension.