Bactericidal cephalosporin antibiotics work by inhibiting bacterial cell wall synthesis. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria, tolerates most beta-lactamases, is effective against strains resistant to gentamicin and other aminoglycosides, and is highly stable against beta-lactamases produced by most clinically important Gram-positive and Gram-negative bacteria. When used in combination with aminoglycoside antibiotics, the efficacy is at least additive, and it has a significant synergistic effect against certain strains.

Broad-spectrum semi-synthetic penicillin has antibacterial effects on hemolytic streptococci, viridans streptococci, pneumococci, penicillin G-sensitive Staphylococcus aureus, gonococci, Haemophilus influenzae, enterococci, Salmonella, Salmonella typhi and Proteus. It has no effect on Staphylococcus aureus that produces penicillinase. Bacteria have complete cross-resistance to this product and ampicillin.

Broad-spectrum semi-synthetic penicillin has antibacterial effects on hemolytic streptococci, viridans streptococci, pneumococci, penicillin G-sensitive Staphylococcus aureus, gonococci, Haemophilus influenzae, enterococci, Salmonella, Salmonella typhi and Proteus. It has no effect on Staphylococcus aureus that produces penicillinase. Bacteria have complete cross-resistance to this product and ampicillin.

Amoxicillin is a broad-spectrum penicillin antibiotic, which can protect it from hydrolysis by β-lactamase when used in combination with potassium clavulanate. It has good effects on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

Potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect and can protect amoxicillin from β-lactamase hydrolysis.

Amoxicillin is a broad-spectrum penicillin antibiotic, which can be used in combination with potassium clavulanate to protect it from hydrolysis by β-lactamase. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative Staphylococci and enterococci, and also has good antibacterial activity against certain β-lactamase-producing Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides fragilis, etc.

Potassium clavulanate itself has only weak antibacterial activity, but it has a strong broad-spectrum β-lactamase inhibitory effect. When used in combination with amoxicillin, it can protect it from β-lactamase hydrolysis.