Fosun Wanbang (Jiangsu) Pharmaceutical Group Co., Ltd.

Nateglinide is an amino acid derivative and an oral antidiabetic drug used to treat patients with type 2 diabetes. The action of nateglinide depends on the function of pancreatic beta cells. Nateglinide binds to the ATP-sensitive K channel receptor on the beta cell membrane and closes it, causing cell depolarization, calcium channel opening, calcium influx, stimulating insulin secretion, and lowering blood sugar. The insulin secretion-promoting effect of nateglinide depends on the glucose level. When the glucose level is low, the insulin secretion is weakened. Nateglinide has a high degree of tissue selectivity and has a low affinity for cardiac muscle and skeletal muscle.

Nateglinide is an amino acid derivative and an oral antidiabetic drug used to treat patients with type 2 diabetes. The action of nateglinide depends on the function of pancreatic beta cells. Nateglinide binds to the ATP-sensitive K channel receptor on the beta cell membrane and closes it, causing cell depolarization, calcium channel opening, calcium influx, stimulating insulin secretion, and lowering blood sugar. The insulin secretion-promoting effect of nateglinide depends on the glucose level. When the glucose level is low, the insulin secretion is weakened. Nateglinide has a high degree of tissue selectivity and has a low affinity for cardiac muscle and skeletal muscle.

Because this product has the physical and chemical characteristics of strong negative charge, it can interfere with many links of the blood coagulation process and has anticoagulant effect in vivo and in vitro. Its mechanism of action is relatively complex, mainly through binding with antithrombin III (AT-III), thereby enhancing the latter's inhibitory effect on activated coagulation factors II, IX, X, XI and XII. Its consequences involve preventing platelet aggregation and destruction, hindering the formation of coagulation activating enzymes; preventing prothrombin from turning into thrombin; inhibiting thrombin, thereby preventing fibrinogen from turning into fibrin.

Inhibits liver glycogenolysis and glycogenoneogenesis, reduces liver output of glucose; promotes liver uptake of glucose and synthesis of liver glycogen; promotes muscle and adipose tissue uptake of glucose and amino acids, promotes the synthesis and storage of protein and fat; causes the liver to produce very low density lipoprotein and activates lipoprotein lipase, promotes the decomposition of very low density lipoprotein; inhibits the decomposition of fat and protein in fat and muscle, inhibits the production of ketone bodies and promotes the utilization of ketone bodies by surrounding tissues.

This product is a hypoglycemic drug. The main effect of insulin is to lower blood sugar, and it also affects protein and fat metabolism, including the following effects: 1. Inhibit liver glycogenolysis and gluconeogenesis, and reduce liver output of glucose; 2. Promote liver uptake of glucose and synthesis of liver glycogen; 3. Promote muscle and adipose tissue to take up glucose and amino acids, promote protein and fat synthesis and storage; 4. Make the liver produce very low density lipoprotein and activate lipoprotein lipase, promote the decomposition of very low density lipoprotein; 5. Inhibit the decomposition of fat and protein in fat and muscle, inhibit the generation of ketone bodies and promote the use of ketone bodies by surrounding tissues.

This product is a hypoglycemic drug. The main effect of insulin is to lower blood sugar, and it also affects protein and fat metabolism, including the following effects: 1. Inhibit liver glycogenolysis and gluconeogenesis, and reduce liver output of glucose; 2. Promote liver uptake of glucose and synthesis of liver glycogen; 3. Promote muscle and adipose tissue to take up glucose and amino acids, promote protein and fat synthesis and storage; 4. Make the liver produce very low density lipoprotein and activate lipoprotein lipase, promote the decomposition of very low density lipoprotein; 5. Inhibit the decomposition of fat and protein in fat and muscle, inhibit the generation of ketone bodies and promote the use of ketone bodies by surrounding tissues.

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