Erythromycin Granules

This product belongs to the macrolide antibiotics, which is the dodecyl sulfate of erythromycin propionate. It has antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Termitomyces pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Pneumoplasma, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor position ("P" position), blocking the transfer RNA (t-RNA) binding to the "P" position, and also blocking the displacement of the polypeptide chain from the acceptor position ("A" position) to the "P" position, thereby inhibiting bacterial protein synthesis. This product is only effective against bacteria with active division.

Main ingredients: Erythromycin.

This product is a suspension granule with aromatic odor and bitter taste.

This product is used as an alternative medicine for the treatment of infections in patients allergic to penicillin, Legionnaires' disease, Mycoplasma pneumonia, Chlamydia pneumoniae pneumonia, genitourinary tract infections, Chlamydia trachomatis conjunctivitis, oral infections caused by anaerobic bacteria, etc.

Oral administration: 1-2g per day for adults, divided into 3-4 times; 20-30mg/kg per day for children, divided into 3-4 times. For the treatment of Legionnaires' disease, 0.5-1.0g per time, 4 times a day for adults. When used as a preventive medication for recurrent rheumatic fever, 0.25g per time, 2 times a day. When used as a preventive medication for infective endocarditis, 1g is taken orally 1 hour before surgery, and 0.5g is taken 6 hours after surgery.

1. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, decreased appetite, etc., and the incidence is related to the dose. 2. Hepatotoxicity is rare. Patients may experience fatigue, nausea, vomiting, abdominal pain, fever, abnormal liver function, and occasionally jaundice. 3. When used in large doses (≥4g/day), especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to excessive blood drug concentration (12mg/L). Most of them can be restored after stopping the drug. 4. Allergies should be manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5. Others, occasional arrhythmia, oral or vaginal Candida infection.

It is contraindicated for patients who are allergic to erythromycin.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: 1. This product can enter the fetal circulation through the placenta, and the possibility of hepatotoxicity after taking this product increases in pregnant women, so it is not suitable for pregnant women. 2. A considerable amount of erythromycin enters breast milk, so breastfeeding should be stopped when using it in lactating women. Precautions for the elderly: This experiment has not been conducted and there are no reliable references.

1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. This product has antagonistic effects with chloramphenicol and lincosamides, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent and can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as in the treatment of meningitis, the two should not be used at the same time. 4. Patients who have been taking warfarin for a long time may experience a prolonged prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be

Keep away from light and store in sealed container.

75 mg (75,000 units) of erythromycin

24 months

Shineway Pharmaceutical Group Ltd.

• Founded in:

  2003-12-30

• Address:

  No. 168, Shiluan Street, Luancheng District, Shijiazhuang City, Hebei Province

• Tax NO.:

  91130000757518418T

• Registered Funds:

  $136 million

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