Homoharringtonine Injection

This product is a bio-ester base with anti-cancer effect extracted from Cephalotaxus plants. It can inhibit the synthesis of eukaryotic cell proteins, disaggregate polyribosomes, and interfere with the function of protein nucleosome sugars. This product also has an inhibitory effect on the synthesis of DNA in cells. In vitro experiments have shown that this product has the strongest killing effect on G1 and G2 phase cells, but has a smaller effect on S phase cells. This product has no cross-resistance with cytarabine, mercaptopurine, etc.

Homoharringtonine

This product is a colorless clear liquid.

It is suitable for various types of acute non-lymphocytic leukemia, and also has certain therapeutic effects on myelodysplastic syndrome (MDS), chronic myeloid leukemia and polycythemia vera.

1. Common dosage for adults: intravenous drip, 1-4 mg per day, add 250-500 ml of 5% glucose injection, slowly drip for more than 3 hours, 4-6 days as a course of treatment, rest for 1-2 weeks and repeat the medication. 2. Common dosage for children: intravenous drip, 0.05-0.1 mg/kg per day according to body weight, 4-6 days as a course of treatment.

1. Bone marrow suppression: This product has an inhibitory effect on all series of hematopoietic cells in the bone marrow. The inhibition of granulocyte series is more serious, followed by erythrocyte series, and the inhibition of megakaryocyte series is less severe. 2. Cardiotoxicity: The more common cardiotoxicity includes sinus tachycardia, atrial or ventricular extrasystoles, and myocardial ischemia manifestations such as S-T segment changes and T wave flatness on the electrocardiogram. Very few patients may have gallop rhythm, atrioventricular block and bundle branch block of varying degrees, atrial fibrillation, etc. 3. Hypotension: Literature reports that when homoharringtonine is taken at a dose of 3.0 mg/m2 per dose, some patients will experience a decrease in blood pressure about 4 hours after administration. 4. Digestive system: Common symptoms are anorexia, nausea, and vomiting. A few patients may develop liver damage. 5. Some patients may experience hair loss and rash. Occasionally, a case of suspected severe anaphylactic shock has been reported.

To avoid fetal death and congenital malformations, pregnant and lactating women should use it with caution.

Precautions during pregnancy and lactation: To avoid fetal death and congenital malformations, pregnant and lactating women should use with caution.

This product is a bio-ester base with anti-cancer effect extracted from Cephalotaxus plants. It can inhibit the synthesis of eukaryotic cell proteins, disaggregate polyribosomes, and interfere with the function of protein nucleosome sugars. This product also has an inhibitory effect on the synthesis of DNA in cells. In vitro experiments have shown that this product has the strongest killing effect on G1 and G2 phase cells, but has a smaller effect on S phase cells. This product has no cross-resistance with cytarabine, mercaptopurine, etc.

Shade, sealed and stored

1ml:1mg

Chengdu Beite Denuo Pharmaceutical Co., Ltd.

• Founded in:

  2018-01-30

• Address:

  No. 66, Kelin Road West Section, Chengdu Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu

• Tax NO.:

  91510115MA6CA1BY4U

• Registered Funds:

  182.776863 yuan

• Email:

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