Cefadroxil Capsules

1. Pharmacology Cefadroxil is a first-generation oral cephalosporin with good antibacterial effect on most strains such as penicillinase-producing and non-penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococcus, Streptococcus pneumoniae, and group A hemolytic streptococci. It also has certain antibacterial activity against Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Haemophilus influenzae, and gonococci. Methicillin-resistant Staphylococci, Enterococci, indole-positive Proteus, Enterobacter, Serratia and other Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. 2. Pharmacology Cefadroxil is low in toxicity. No death occurred when a high dose of 12,600 mg/kg was given to newborn rats; dogs were given 600 mg/kg of this product orally every day, and rats were given 1,000 mg/kg of this product orally every day for 6 consecutive months, and no toxic reactions were produced in various tissues and organs.

The main ingredient of this product is cefoperazone, and its chemical name is (6R,7R)-3-methyl-7-[(R)-2-amino-2-(4-hydroxyphenyl)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate. Molecular formula: C16H17N3O5SH2O.

This product is in the form of capsules.

It is suitable for urinary tract infections, skin and soft tissue infections, acute tonsillitis, acute pharyngitis, otitis media and lung infections caused by sensitive bacteria. This product is an oral preparation and should not be used for severe infections.

Common dosage for adults: Oral, 0.5-1.0g at a time, twice a day. Common dosage for children: 15-20mg/kg per body weight, twice a day. Group A hemolytic streptococcal pharyngitis and tonsillitis: 15mg/kg every 12 hours, for a course of at least 10 days; for adults with impaired renal function, the first dose is 1g saturation dose, and then the dosing interval is extended according to the degree of renal function impairment. When the creatinine clearance rate is 25-50ml/min, 10-25ml/min and 0-10ml/min, take 500mg every 12 hours, 24 hours and 36 hours respectively.

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever, and occasionally anaphylactic shock. 3. Nervous system reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4. Transient renal damage may occasionally occur during the use of this product. 5. Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported.

It is contraindicated for patients with a history of allergy to cephalosporins and a history of anaphylactic shock or immediate reaction to penicillin.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: Pregnant women must have specific indications for medication. This product can also enter breast milk. Although there are no reports of problems with the use of cephalosporins in lactating women, it is still necessary to weigh the pros and cons before using it. Precautions for the elderly: This experiment has not been conducted and there are no reliable references.

Probenecid can increase the blood concentration of this product and delay renal excretion.

Keep away from light, seal tightly and store in a cool dark place.

0.5g

24 months

Suzhou Chung- HWA Chemical & Pharmaceutical Industrial Co., Ltd.

• Founded in:

  1993-04-27

• Address:

  No. 66, Yong'an Road, Suzhou High-tech Zone

• Tax NO.:

  913205056081966464

• Registered Funds:

  $25.5 million

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