Glipizide Tablets

1. This product is a second-generation sulfonylurea antidiabetic drug. It is effective for most patients with type 2 diabetes, and can reduce fasting and postprandial blood sugar, and reduce glycosylated hemoglobin (HbAlc) by 1% to 2%. 2. The main function of this type of drug is to stimulate the pancreatic b cells to secrete insulin, but the prerequisite is that the pancreatic b cells still have a certain function of synthesizing and secreting insulin. 3. Its mechanism is to specifically bind to the sulfonylurea receptor on the b cell membrane, thereby closing the K channel, causing changes in membrane potential, opening the Ca2 channel, and increasing intracellular Ca2, which promotes insulin secretion. 4. In addition, there are extra-pancreatic effects, including improving the insulin resistance of peripheral tissues (such as liver, muscle, and fat).

Glipizide

White or off-white tablets.

Mainly used to treat non-insulin-dependent (type Ⅱ) diabetes.

Oral administration. Take 30 minutes before meals. Start with 2.5-5 mg per day, once a day, before breakfast. The dose can be gradually adjusted according to the situation to achieve satisfactory control of blood sugar concentration. When the daily dose is more than 10 mg, it can be taken in 2-3 times. The maximum daily dose should not exceed 30 mg. For patients who take other oral sulfonylurea hypoglycemic drugs, when switching to treatment, the patient needs to be carefully observed for 1-2 weeks to prevent hypoglycemia.

Nausea, vomiting, diarrhea, abdominal pain, headache, etc., the incidence rate is 1-2%, but the symptoms will disappear with continued treatment. Some patients may develop temporary rashes and occasional hypoglycemia.

1. Those who are allergic to sulfonamides. 2. Patients with confirmed diagnosis of type 1 diabetes. 3. Patients with type 2 diabetes accompanied by stressful conditions such as ketoacidosis, coma, severe burns, infection, trauma, and major surgery. 4. Patients with impaired liver and kidney function. 5. Patients with leukopenia.

Precautions for children: Not tested. Precautions for pregnancy and lactation: 1. Animal experiments and clinical observations have shown that sulfonylurea hypoglycemic drugs can cause stillbirth and fetal malformation, so they are contraindicated for pregnant women. 2. This type of drug can be excreted through breast milk, so it is not suitable for nursing mothers to use it to avoid hypoglycemia in infants. Precautions for the elderly: Start with a small dose and gradually adjust the dose.

1. This drug can increase its hypoglycemic effect when used in combination with coumarins, monoamine oxidase inhibitors, phenylbutazone, sulfonamides, chloramphenicol, cyclophosphamide, probenecid, and salicylic acid drugs. 2. When used in combination with adrenaline, adrenocortical hormones, oral contraceptives, and thiazide diuretics, its hypoglycemic effect can be reduced. 3. Be cautious when used in combination with beta-blockers. 4. Gastrointestinal diseases that shorten the retention time of this product in the gastrointestinal tract can affect the pharmacokinetics and efficacy of this product.

Keep away from light and store in a sealed container.

5 mg

48 months

Suzhou Chung- HWA Chemical & Pharmaceutical Industrial Co., Ltd.

• Founded in:

  1993-04-27

• Address:

  No. 66, Yong'an Road, Suzhou High-tech Zone

• Tax NO.:

  913205056081966464

• Registered Funds:

  $25.5 million

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