Nifedipine sustained-release tablets (Ⅰ)
Function and Efficacy
Nifedipine is a dihydropyridine calcium antagonist that selectively inhibits the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibits the release of calcium ions from intracellular pools without changing the plasma calcium ion concentration. Pharmacology: This product can simultaneously relax the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen in patients with coronary artery spasm, and relieve and prevent coronary artery spasm. It can also inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption. On the other hand, it can relax peripheral resistance vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload. This product can delay the sinus node function and atrioventricular conduction of isolated hearts; electrophysiological studies of whole animals and humans have not found that this product has the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinus node, and slowing down the sinus node rate. Toxicology (carcinogenicity, mutagenicity and reproductive toxicity) No carcinogenic effect. No mutagenicity. Large doses can reduce the fertility of female mice, cause teratogenesis, and induce abortion (increased drug absorption rate in fetal mice, increased fetal mortality, and decreased survival rate of newborn mice). Pregnant monkeys taking 2/3 to 2 times the maximum human dose can cause small placenta and chorionic dysplasia; giving rats 3 times the maximum human dose can cause prolonged pregnancy.
Ingredients
The main ingredient of this product is: nifedipine.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| NifedipineIngredients |
Nifedipine is a dihydropyridine calcium antagonist that selectively inhibits the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibits the release of calcium ions from intracellular reservoirs without changing the plasma calcium ion concentration. It can simultaneously relax the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen to patients with coronary artery spasm, and relieve and prevent coronary artery spasm. It can also inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption. On the other hand, it can relax peripheral resistance vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload. It can delay the sinoatrial node function and atrioventricular conduction of isolated hearts; electrophysiological studies on whole animals and humans have not found that this product has the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinoatrial node, and slowing down the sinoatrial node rate. More |
21829-25-4 | 75 |
Appearance
This product is a film-coated tablet, which turns yellow after removing the film coating.
Indication
Various types of hypertension and angina pectoris
Usage and Dosage
Oral. 1~2 tablets at a time, 2 times a day. Maximum dose: 4 tablets at a time, 12 tablets a day
Adverse Reactions
1. Liver: Occasionally jaundice and elevated glutamate oxaloacetate aminotransferase and glutamate propionate aminotransferase may occur. 2. Circulatory system: Occasionally chest pain, headache, flushing, dizziness, palpitations, decreased blood pressure, lower limb edema, etc. may occur. 3. Allergies: Occasionally allergic symptoms such as measles and itching may occur. 4. Digestive system: Occasionally abdominal pain, nausea, loss of appetite, constipation, etc. may occur. 5. Oral cavity: Gum hypertrophy may occur. 6. Metabolic abnormalities: Occasionally symptoms of hyperglycemia may occur.
Precautions
Not suitable for children and pregnant women
Special Population Medication
Precautions for children: Not for use in children Precautions for pregnancy and lactation: Not for use in pregnant women Precautions for the elderly: No such experiment has been conducted and no reliable references are available
Drug Interactions
Not yet clear
Storage
Keep in a light-proof and airtight container.
Packaging Specification
10 mg
Validity Period
24 months
Manufacturer
Yabao Pharmaceutical Group Co., Ltd.
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Founded in:
1999-01-26 -
Address:
No. 43, Fumin Road, Ruicheng County, Yuncheng City, Shanxi Province -
Tax NO.:
91140000701108049W -
Registered Funds:
720,000,940 yuan -
Website:
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Email: