Mannitol injection

Mannitol is a monosaccharide that is not metabolized in the body. After being filtered by the glomerulus, it is rarely reabsorbed in the renal tubules, thus playing an osmotic diuretic role. (1) Tissue dehydration. It increases plasma osmotic pressure, causing water in tissues (including eyes, brain, cerebrospinal fluid, etc.) to enter the blood vessels, thereby reducing tissue edema, intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and pressure. For more details, please refer to the instructions.

The main ingredient of this product is: mannitol.

(1) Tissue dehydration drugs. Mannitol injection is used to treat brain edema caused by various reasons, reduce intracranial pressure, and prevent brain herniation. (2) Reduce intraocular pressure. It can effectively reduce intraocular pressure and is used when other intraocular pressure-lowering drugs are ineffective or before intraocular surgery. (3) Osmotic diuretics. It is used to identify oliguria caused by prerenal factors or acute renal failure. It can also be used to prevent acute tubular necrosis caused by various reasons. (4) As an auxiliary diuretic measure to treat nephrotic syndrome and ascites caused by liver cirrhosis, especially when accompanied by hypoproteinemia. For other details, please refer to the instructions.

See the instruction manual for details

(1) Water and electrolyte disorders are the most common. ① Rapid intravenous injection of large amounts of mannitol can cause accumulation of mannitol in the body, rapid and large increase in blood volume (especially in acute and chronic renal failure), leading to heart failure (especially in cases of heart damage), dilutional hyponatremia, and occasionally hyperkalemia; ② Inappropriate excessive diuresis leads to reduced blood volume and aggravated oliguria; ③ Large amounts of intracellular fluid transferred to the extracellular space can cause tissue dehydration and central nervous system symptoms. (2) Chills and fever. For other details, please refer to the instructions.

① Anuric patients diagnosed with acute tubular necrosis, including those who do not respond to mannitol trials, because mannitol accumulation causes increased blood volume and increases the burden on the heart; ② Patients with severe water loss; ③ Patients with active intracranial bleeding, because volume expansion aggravates bleeding, except during intracranial surgery; ④ Acute pulmonary edema, or severe pulmonary congestion.

Precautions during pregnancy and lactation: (1) Mannitol can pass through the placental barrier. (2) It is not clear whether it can be secreted through breast milk. Precautions for the elderly: Elderly people are more likely to suffer from kidney damage when using this drug, and the chance of kidney damage increases with age. Appropriately control the dosage.

(1) It can increase the toxic effects of digitalis and is related to hypokalemia. (2) It can increase the diuretic and intraocular pressure-lowering effects of diuretics and carbonic anhydrase inhibitors. The dose should be adjusted when combined with these drugs.

normal temperature

250ml*50g/piece

Jiangsu Yabang Shengyuan Pharmaceutical Co., Ltd.

• Founded in:

  1979-11-07

• Address:

  No. 801, Xin'an Avenue, Binhai Pharmaceutical Industrial Park, Binhai County, Yancheng City

• Tax NO.:

  91320922703863611B

• Registered Funds:

  30 million yuan

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