DL-Mannitol
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DL-Mannitol
structure -
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CAS No:
87-78-5
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Formula:
C6H14O6
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Chemical Name:
DL-Mannitol
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Synonyms:
Mannitol;NSC 9256;DL-Mannitol;133-43-7;5149-40-6;36413-61-3
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CAS No:
Description
D-mannitol (D-mannohexan-1.2.3.4.5.6-hexaol) is a constituent of several plants
including the Manna ash, several edible plants, and seaweed. Parts of the latter
contain up to 10 % mannitol by weight. The solubility in water is approximately 230 g/L at room temperature and it increases with increasing temperature. Mannitol
is stable under the common processing conditions of foods.
Mannitol is approximately 50 % as sweet as sucrose and non-cariogenic.
In the European Union, maltitol is appro
Characteristics
121.38000
-3.1
D-mannitol appears as odorless white crystalline powder or free-flowing granules. Sweet taste. (NTP, 1992)
1.596 g/cm3
166-168ºC
494.9ºC at 760 mmHg
292.5ºC
1.597
177.3g/L(25 ºC)
Mannitol solutions should be stored at room temperature and protected from freezing.
Specific optical rotation: -0.49 deg @ 25 °C/D (water)
Odorless
Sweetish taste
13.5(at 25 °C)
Safety Information
3
S24/25
Mannitol 25% (Invenex) was chemically and physically stable after five autoclavings at 250 deg F for 15 min.
DL-Mannitol Use and Manufacturing
Dehydration drugs, diuretics. Treat cerebral edema and glaucoma, acute oliguria, prevent acute renal failure, and treat edema of nephrotic syndrome. Note: For patients with active intracranial hemorrhage, injection is prohibited (except for craniotomy). Used as analytical reagents, also used in the synthesis of resins and pharmaceuticals.
Drug Function and Efficacy
It participates in the metabolism of fat, protein, sugar, nucleic acid and nucleotide in the body and is the main source of energy in the body; it inhibits the slow calcium ion influx of slow-reacting fibers, blocks or delays the forward conduction in the atrioventricular nodal reentry pathway, and large doses may also block or delay the forward and retrograde conduction of the bypass pathway; it has a short-term and strong effect of enhancing the vagus nerve, and can terminate arrhythmias caused by atrioventricular nodal reentry and bypass pathway reentry mechanisms.
Registered Holders
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AVT (SHANGHAI) PHARMACEUTICAL TECH CO LTD
Active
United States
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ROQUETTE FRERES
Active
France
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Beijing Representative Office of French Roget Company
Active
China
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