Lamivudine Tablets

Lamivudine is a nucleoside antiviral drug. It has a strong inhibitory effect on hepatitis B virus (HBV) in vitro and in experimentally infected animals. Lamivudine can be metabolized in HBV-infected cells and normal cells to produce lamivudine triphosphate, which is the active form of lamivudine and is both an inhibitor of HBV polymerase and a substrate of this polymerase. Lamivudine triphosphate penetrates into the viral DNA chain and blocks the synthesis of viral DNA. Lamivudine triphosphate does not interfere with the metabolism of deoxynucleosides in normal cells. It has a weak inhibitory effect on mammalian DNA polymerase a and b and has almost no effect on the DNA content of mammalian cells. Lamivudine has no obvious toxicity to the structure, DNA content and function of mitochondria. The results of serum HBVDNA detection in most hepatitis B patients showed that lamivudine can rapidly inhibit HBV replication, and its inhibitory effect lasts throughout the treatment process, while reducing serum aminotransferase to normal.

The main ingredient of this product is lamivudine

This medicine is a grey diamond-shaped film-coated tablet with GXEJ7 engraved on one side.

1. Suitable for chronic hepatitis B with hepatitis B virus replication.

Oral administration: adults 0.1g at a time, once a day.

Common adverse reactions include upper respiratory tract infection-like symptoms, headache, nausea, malaise, abdominal pain and diarrhea. The symptoms are generally mild and can be relieved on their own.

1. Patients who are allergic to this product are prohibited from using it; 2. Patients who are pregnant for less than 3 months should not use this product.

Precautions for children: There is no efficacy and safety data for patients under 16 years old. Precautions for pregnancy and lactation: It is contraindicated for patients within 3 months of pregnancy. Precautions for the elderly: For elderly patients whose renal excretion function decreases due to age, there is no significant change in lamivudine metabolism, and it is only affected when the creatinine clearance rate is 30ml/min.

1. When lamivudine is used simultaneously with drugs with the same excretion mechanism (such as trimethoprim, sulfamethoxazole), the blood concentration of lamivudine can increase by 40%, which has no clinical significance, but patients with renal impairment should pay attention. 2. When used in combination with zidovudine, the latter's peak blood concentration (Cmax) can be increased, but it does not affect the elimination and area under the drug-time curve of the two.

Store below 30°C.

0.15g

24 months

Anhui Biochem Bio-Pharmaceutical Co., Ltd.

• Founded in:

  2003-12-17

• Address:

  No. 30 Hongfeng Road, High-tech Development Zone, Hefei City, Anhui Province

• Tax NO.:

  91340100752990430A

• Registered Funds:

  70 million yuan

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