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Ethacridine Lactate Injection

Function and Efficacy

This product is administered intra-amniotically and intrauterinely. The drug can cause necrosis of intrauterine decidual tissue and produce endogenous prostaglandins, causing uterine contraction. Ethacridine also has a direct excitatory effect on uterine muscles.

Ingredients

Ethacridone lactate, chemical name: 6,9-diamino-2-ethoxyacridone lactate hydrate.

Name Description Content CAS NO. Manufacturer
6,9-DIAMINO-2-ETHOXYACRIDINE LACTATEIngredients

The drug can cause necrosis of the intrauterine decidual tissue and produce endogenous prostaglandins, which can cause uterine contractions. Ethacridine also has a direct excitatory effect on uterine muscles.

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1837-57-6 6

Appearance

This product is a yellow clear liquid.

Indication

Mid-pregnancy labor-inducing drugs are used to terminate pregnancies between 12 and 26 weeks.

Usage and Dosage

(1) Intra-amniotic cavity medication After emptying the bladder, the pregnant woman lies on her back and selects the most prominent part of the uterus. The point where the amniotic fluid fluctuates significantly is the puncture point. Use gauze to hold a No. 7 lumbar puncture needle and pierce it vertically into the abdominal wall. There is a sense of emptiness when entering the amniotic cavity. Continue to insert the needle for 0.5 to 1 cm and then pull out the needle core. After the amniotic fluid gushes out, connect the syringe containing 100 mg of rivanol solution to the puncture needle. After withdrawing the amniotic fluid to confirm that it is correct, slowly inject the drug solution. The amniotic fluid must be withdrawn before withdrawing the needle. Before withdrawing the needle, insert the needle core into the needle and withdraw the needle quickly. Cover the needle with sterile gauze and gently press the needle hole. (2) Intra-uterine and extra-amniotic cavity medication After emptying the bladder, the pregnant woman takes the lithotomy position. After routine disinfection of the vulva, vagina, and cervix, clamp the anterior lip of the cervix with a cervical clamp, insert the rubber catheter along the cervix into the uterine cavity, and inject 100 ml of the prepared rivanol solution (containing 100 mg of the drug, diluted with water for injection) into the catheter. The lower end of the catheter is folded in half and tied tightly with thread, rolled up in the vagina, and a piece of gauze is inserted to secure it. The gauze and catheter are removed 24 hours after the operation.

Adverse Reactions

(1) In case of poisoning, symptoms include oliguria, anuria and jaundice, and severe damage to liver and kidney function. (2) About 3% to 4% of pregnant women have a fever of over 38°C. (3) Bleeding. Induced labor with rivanol is prone to placental retention or partial placenta and fetal membranes remaining, causing massive bleeding. (4) The incidence of soft birth canal injury is 0.5% to 3%, and the most common is cervical tearing or perforation of the anterior or posterior wall of the cervical canal. (5) Very few pregnant women have allergic reactions.

Precautions

Not yet clear.

Special Population Medication

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Drug Interactions

There is no information on the interaction of this product with other drugs.

Storage

Keep away from light and store in a sealed container.

Packaging Specification

2ml:50mg

Validity Period

24 months

Manufacturer

GuangXi HeFeng Pharmaceutical Limited Liability Company

  • Founded in:

    2000-09-18
  • Address:

    Guangxi Donglan County Third Development Zone
  • Tax NO.:

    914512247188985773
  • Registered Funds:

    5.5 million yuan
  • Website:

  • Email:

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