Piperacillin Sodium and Sulbactam Sodium for Injection

This product (i.e., this compound, the same below) is a compound preparation composed of piperacillin sodium and sulbactam sodium in a ratio of 4:1. Piperacillin is a semi-synthetic penicillin that inhibits the synthesis of bacterial cell walls by binding to bacterial penicillin-binding proteins (PBPs) to kill bacteria. It has the characteristics of broad spectrum and low toxicity, but is easily hydrolyzed by β-lactamase produced by bacteria to produce drug resistance. Sulbactam is a β-lactamase inhibitor that can inhibit Ⅱ-Ⅴ type β-lactamase and is a competitive and irreversible inhibitor. The combined use of piperacillin and sulbactam enhances the antibacterial activity of piperacillin, expands the antibacterial spectrum, and enhances its antibacterial activity against piperacillin-resistant enzyme-producing bacteria.

This product is a compound preparation, and its components are: each bottle contains 2.0g of piperacillin and 0.5g of sulbactam.

This product is white or off-white powder or crystalline powder.

It is suitable for the following infections caused by β-lactamase-producing pathogens that are resistant to piperacillin and sensitive to this product. When used to treat mixed infections caused by bacteria that are sensitive to piperacillin alone and β-lactamase-producing bacteria that are resistant to piperacillin alone and sensitive to this product, no other antibiotics are needed. 1. Respiratory system infections: including acute bronchitis, pneumonia, acute exacerbation of chronic bronchitis, bronchiectasis combined with infection, etc. 2. Urinary system infections: including simple urinary system infections and complicated urinary system infections.

Usage: intravenous drip. Before use, dissolve each bottle of this product with an appropriate amount (generally at least 5ml) of 5% glucose solution and 0.9% sodium chloride injection, and then dilute it with the same solvent to 500ml for intravenous drip, and the drip time is 60-120 minutes. Dosage: Adults take 1.5g each time (i.e., 1g of piperacillin, 0.5g of sulbactam) or 3.0g (i.e., 2.0g of piperacillin, 1.0g of sulbactam), once every 12 hours. For severe or refractory infections, take 6.0g each time (i.e., 4.0g of piperacillin, 2.0g of sulbactam), once every 12 hours. The maximum daily dose is 12.0g (i.e., 8.0g of piperacillin, 4.0g of sulbactam), and the maximum daily dose of sulbactam is 4.0g. For patients with renal insufficiency, adjust the dose as appropriate.

Generally speaking, patients tolerate this product well, and only a few patients may experience adverse reactions. 1 Gastrointestinal reactions: Like other antibiotics, the use of this product may cause diarrhea, loose stools, and occasionally nausea, vomiting, and gastrointestinal flatulence. Pseudomembranous colitis is rare. 2 Skin reactions: Like penicillin and cephalosporins, this product can cause rash and itchy skin. 3 Allergic reactions: Like penicillin and cephalosporins, this product can cause allergic reactions. Therefore, you must inquire about the allergy history before taking the drug. It is contraindicated for those with a history of penicillin allergy. 4 Local reactions: Like other β-lactam antibiotics, this product can cause local irritation reactions at the injection site, pain, phlebitis, thrombophlebitis,

It is contraindicated for patients who are allergic to penicillins, cephalosporins or β-lactamase inhibitors or have a history of allergy to the above drugs.

1. When this product is used in combination with probenecid, it can reduce the renal clearance of this product and prolong its half-life. 2. When this product is used simultaneously with tobramycin, it can reduce the area under the curve and renal clearance of tobramycin. 3. The activity of aminoglycoside antibiotics can be reduced due to the presence of penicillins. 4. When piperacillin is used simultaneously with the non-polar muscle relaxant vecuronium bromide, the neuromuscular blocking effect of vecuronium bromide can be prolonged. 5. When piperacillin is taken simultaneously with heparin, oral anticoagulants and other drugs that may affect the blood coagulation system and platelet function, coagulation indicators should be monitored regularly.

Sealed, stored in a cool, dark and dry place. Validity period: two years

1.25g (including C23H27N5O7S1.0g and C8H11NO5S0.25g)

Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

• Founded in:

  1993-08-11

• Address:

  No. 978 Chuansha Road, Pudong New Area, Shanghai

• Tax NO.:

  91310115133738906M

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  1,052,429,132 yuan

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