Sulbactam pivoxil

The main ingredient of this product is sultamicillin tosylate, whose chemical name is () hydroxymethyl-(2S,5R,6R)-6[(R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxido-4-thia-1-azabicyclo[3,2,0]n-heptane-2-carboxylate, 2S,5R-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]n-heptane-2-carboxylate.

Not yet clear.

The main ingredient of this product is sultamicillin tosirate, and its chemical name is () Hydroxymethyl-(2S, 5R, 6R)-6-[(R)-(2-amino-2-phenylacetylamino)]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]n-heptane-2-carboxylate, (2S, 5R)-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]n-heptane-2-carboxylate S, S-dioxide p-toluene phosphate.

1. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2beta;), and the toxicity may also increase. 2. When this product is used in combination with allopurinol, the incidence of rash increases significantly, so it should be avoided. 3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6. Antibiotics such as chloramphenicol, erythromycin, tetracyclines, and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it is not suitable to be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently need bactericidal drugs. 7. This product can enhance the effect of warfarin.

This product is a compound preparation, and its components are: each bottle contains 2.0g of piperacillin and 0.5g of sulbactam.

1. When this product is used in combination with probenecid, it can reduce the renal clearance of this product and prolong its half-life. 2. When this product is used simultaneously with tobramycin, it can reduce the area under the curve and renal clearance of tobramycin. 3. The activity of aminoglycoside antibiotics can be reduced due to the presence of penicillins. 4. When piperacillin is used simultaneously with the non-polar muscle relaxant vecuronium bromide, the neuromuscular blocking effect of vecuronium bromide can be prolonged. 5. When piperacillin is taken simultaneously with heparin, oral anticoagulants and other drugs that may affect the blood coagulation system and platelet function, coagulation indicators should be monitored regularly.