Clomipramine Hydrochloride Tablets

This product is a tricyclic antidepressant. Its main function is to block the reuptake of norepinephrine and 5-hydroxytryptamine in the central nervous system. It has a stronger blocking effect on the reuptake of 5-hydroxytryptamine, and exerts antidepressant and antianxiety effects. It also has sedative and anticholinergic effects.

The main ingredient of this product is clomipramine hydrochloride, and its chemical name is: N,N-dimethyl-10,11-dihydro-3-chloro-5H-dibenzo[b,f]azepine-5-propylamine hydrochloride.

This product is a sugar-coated tablet, which appears white or slightly yellow after removing the sugar coating.

It is used to treat various depressive states. It is also commonly used to treat obsessive-compulsive neurosis and phobic neurosis.

For oral treatment of depression and obsessive-compulsive disorder, the initial dose is 25 mg once, 2-3 times a day, and slowly increased to 150-250 mg per day within 1-2 weeks, and the maximum dose should not exceed 300 mg per day. For the treatment of phobic neurosis, the dose is 75-150 mg per day, taken orally in 2-3 times.

Anticholinergic reactions may occur in the early stage of treatment, such as hyperhidrosis, dry mouth, blurred vision, dysuria, constipation, etc. Adverse reactions of the central nervous system may include drowsiness, tremor, and dizziness. Postural hypotension may occur. Occasionally, epileptic seizures, abnormal electrocardiograms, bone marrow suppression, or toxic liver damage may occur.

Patients with severe heart disease, recent history of myocardial infarction, epilepsy, glaucoma, urinary retention and allergy to tricyclic drugs.

Precautions for children: Children under 6 years old are prohibited to use this product. Children over 6 years old should reduce the dosage as appropriate. Precautions for pregnancy and lactation: Pregnant women should use this product with caution. Lactating women should stop breastfeeding while using this product. Precautions for the elderly: Start with a small dose, increase the dose slowly, and reduce the dose as appropriate.

1. When this product is used in combination with sultopride, the risk of ventricular arrhythmias may increase, and in severe cases, it may lead to torsades de pointes. 2. When this product is used in combination with ethanol or other central nervous system depressants, the central nervous system depressant effect is enhanced. 3. When this product is used in combination with adrenaline and norepinephrine, it is easy to cause paroxysmal hypertension and arrhythmias. 4. When this product is used in combination with clonidine, the latter's antihypertensive effect is weakened. 5. When this product is used in combination with anticonvulsants, the effect of anticonvulsants may be reduced. 6. When this product is used in combination with fluoxetine or fluvoxamine, the plasma concentrations of both may be increased, resulting in convulsions and increased adverse reactions. 7

Keep away from light and store in sealed container.

25mg

24 months

Tipr Pharmaceutical Co., Ltd.

• Founded in:

  1994-08-18

• Address:

  No. 29, Huixin Road, Binhai Science and Technology Park, Binhai Hi-tech Zone, Tianjin

• Tax NO.:

  91120116238991799D

• Registered Funds:

  50 million yuan

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