Cefuroxime Sodium for Injection

This product is a second-generation cephalosporin antibiotic. The antibacterial activity against Gram-positive cocci is similar to or slightly worse than that of the first-generation cephalosporins, but it is quite stable against beta-lactamase produced by Staphylococci and Gram-negative bacilli. Methicillin-resistant Staphylococci, Enterococci and Listeria are resistant, and other positive cocci (including anaerobic cocci) are sensitive to this product. The antibacterial activity against Staphylococcus aureus is worse than that of cefazolin, and 1-2 mg/L can inhibit all Staphylococcus aureus that are sensitive and resistant to penicillin, respectively. It has strong antibacterial activity against Haemophilus influenzae, and Escherichia coli, Proteus mirabilis, etc. may be sensitive to this product; indole-positive Proteus, Citrobacter and Acinetobacter have poor sensitivity to this product, most Serratia are resistant, Pseudomonas aeruginosa, Campylobacter and Bacteroides fragilis are resistant to this product. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate the transpeptidase, inhibit the synthesis of the bacterial septum and cell wall, affect the cross-linking of the cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die.

Cefuroxime Sodium

This product is off-white or slightly yellow powder or crystalline powder.

Used for diseases caused by sensitive bacteria.

Intramuscular injection, intravenous injection or intravenous drip. 1. Intramuscular injection: 0.25g of Cefuroxime Sodium for Injection is added to 1ml of water for injection or 0.75g of Cefuroxime Sodium for Injection is added to 3ml of water for injection, and gently shaken to make an opaque suspension. 2. Intravenous injection: 0.25g of Cefuroxime Sodium for Injection is added to at least 2ml of water for injection or 0.75g of Cefuroxime Sodium for Injection is added to at least 6ml of water for injection to dissolve into a yellow clear solution. 3. Intravenous drip: 1.5g of Cefuroxime Sodium for Injection can be dissolved in 50ml of water for injection or combined with most commonly used intravenous injection solutions (except aminoglycosides). General or moderate infection: 0.75g once, 3 times a day, intramuscular or intravenous injection. Severe infection: Double the dose, 1.5g once, 3 times a day, intravenous drip for 20 to 30 minutes. Infants and children are given 30 to 100mg/kg per day according to their body weight, divided into 3 to 4 doses.

1 Occasionally, skin rash and elevated serum aminotransferase may occur, but the symptoms disappear after discontinuation of the drug. 2 There is a cross-allergic reaction with penicillin. 3 According to literature reports, long-term use of this product can lead to the proliferation of non-sensitive bacteria and gastrointestinal disorders, including pseudomembranous colitis, which rarely occurs in the middle and late stages of treatment. 4 Rare transient decreases in hemoglobin concentration, eosinophilia, and leukocytopenia and neutrophilia may occur, but the symptoms disappear after discontinuation of the drug. 5 When injected intramuscularly, there will be temporary pain at the injection site, especially when the dose is large.

Patients who are allergic to this product and cephalosporin antibiotics are contraindicated.

1. This product is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium methanesulfonate, polymyxin B sulfate, erythromycin gluconate, erythromycin lactobionate, lincomycin, sulfisoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium glucoheptonate, diphenhydramine hydrochloride and other antihistamines, lidocaine, norepinephrine, metaraminol, methylphenidate, succinylcholine, etc. Occasionally, it may also be contraindicated with the following drugs: penicillin, methicillin, hydrocortisone succinate, phenytoin sodium, prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. 2. This product cannot be dissolved in sodium bicarbonate solution. 3. This product cannot be administered in the same injection container with other antibacterial drugs. 4. This product can cause nephrotoxicity when used in combination with strong diuretics.

Protect from light, seal tightly, and store in a cool and dry place.

3.0g

Guangzhou Baiyunshan Tianxin Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-28

• Address:

  No. 808, Binjiang East Road, Haizhu District, Guangzhou

• Tax NO.:

  91440101190485108B

• Registered Funds:

  45.693 million yuan

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