Metronidazole suppositories
Function and Efficacy
This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. In vitro tests have shown that when the drug concentration is 1~2mg/L, the histolytica amoeba can undergo morphological changes in 6~20 hours and all are killed within 24 hours. When the concentration is 0.2mg/L, the histolytica amoeba can be killed within 72 hours. This product has a strong effect of killing trichomonas, and its mechanism is unknown. Metronidazole has a killing effect on cells and anaerobic microorganisms growing under hypoxic conditions. The metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death.
Ingredients
Metronidazole.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| MetronidazoleIngredients |
This product is a nitroimidazole derivative that can inhibit the redox reaction of amoeba and break the nitrogen chain of the protozoa. When the drug concentration is 1~2mg/L, the histolytica amoeba can undergo morphological changes in 6~20 hours and all are killed within 24 hours. When the concentration is 0.2mg/L, the histolytica amoeba can be killed within 72 hours. This product has a strong effect of killing trichomonas, and its mechanism is unknown. Metronidazole has a killing effect on cells growing under hypoxic conditions and anaerobic microorganisms. The metabolites generated when it is reduced in the human body also have anti-anaerobic effects, inhibiting the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and ultimately causing bacterial death. More |
443-48-1 | 39 |
Appearance
This product is a milky white to light yellow torpedo-shaped suppository.
Indication
It is used to treat Trichomonas vaginitis. It can also be used to prevent and treat anaerobic infection after minor gynecological surgery.
Usage and Dosage
Vaginal administration: 0.5g at a time, 0.5g once every night, for 7 to 10 days. Metronidazole tablets should be taken at the same time, 0.2g each time, four times a day, for seven consecutive days.
Adverse Reactions
Adverse reactions occur in 15% to 31% of cases, with digestive tract reactions being the most common, including nausea, vomiting, loss of appetite, and abdominal cramps, which generally do not affect treatment; neurological symptoms include headache, dizziness, occasional paresthesia, limb numbness, ataxia, multiple neuritis, etc., and high doses can cause convulsions. A small number of cases develop urticaria, flushing, itching, cystitis, dysuria, metallic taste in the mouth, and leukopenia, all of which are reversible and recover on their own after stopping the drug.
Precautions
It is forbidden to use in pregnant and lactating women.
Special Population Medication
Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.
Drug Interactions
Not yet clear.
Storage
Keep in a dark place, sealed and stored in a cool place below 30℃
Packaging Specification
0.5g
Validity Period
36 months.
Manufacturer
China National Pharmaceutical Industry Corporation Ltd
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Founded in:
2002-12-30 -
Address:
No. 6, Niuhui South 1st Street, Niulanshan Town, Shunyi District, Beijing -
Tax NO.:
91110000710930704J -
Registered Funds:
230 million yuan -
Website:
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Email: