Metronidazole vaginal gel

Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobes. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus. Its bactericidal concentration is slightly higher than the inhibitory concentration. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, thereby acting on the DNA metabolism process of bacteria and promoting cell death.

Metronidazole

This product is a slightly yellow transparent gel.

For the treatment of bacterial vaginosis.

For intravaginal use, once in the morning and once in the evening, 5g each time (equivalent to 37.5mg of metronidazole), 5 to 7 days as a course of treatment. The patient takes a recumbent position, removes the front cover of the applicator, inserts the front end of the applicator deep into the vagina, and pushes the booster rod to allow the gel to enter the deep vagina. Take out the applicator and discard it.

1. Reproductive tract: Candida cervicitis and vaginitis, vaginal, perineal or vulvar itching, frequent urination, vaginal or vulvar burning sensation, discomfort, irritation (not caused by Candida) and vulvar swelling. 2. Long-term high-dose use can cause epileptic seizures and peripheral neuropathy after absorption through the mucosa. The latter is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use may cause persistent peripheral neuropathy. 3. Other common adverse reactions include: (1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. (2) Reversible neutropenia. (3) Allergic reactions, rash, urticaria, itching, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia

It is contraindicated for patients who are allergic to this product or azole drugs and those with active central nervous system diseases and blood diseases.

Precautions for children: Children should use with caution. Precautions for pregnancy and lactation: Animal experiments have found that metronidazole is toxic to the fetus after intraperitoneal administration. However, there is currently a lack of sufficient and rigorous controlled studies on pregnant and lactating women, so pregnant and lactating women are prohibited from using this product. Precautions for the elderly: Due to decreased liver function, the pharmacokinetics of this product are changed when used in the elderly, so it should be used with caution.

After large-scale use of this product, it is absorbed through the mucosa and may also produce drug interactions similar to those of systemic medications, such as inhibiting the metabolism of warfarin and other oral anticoagulants to prolong the prothrombin time, interfering with the metabolism of disulfiram and the results of serum aminotransferase and lactate dehydrogenase assays, and combining with liver microsomal enzyme inducers or inhibitors to accelerate or slow down the metabolism of this product in the liver.

Keep tightly closed in a cool place.

5 g: 37.5 mg

Tentative 18 months

Tongfang Pharmaceutical Group Co., Ltd.

• Founded in:

  1993-12-08

• Address:

  No. 23, Xikang Road, Badaling Town, Yanqing District, Beijing (Yanqing Park, Zhongguancun Science Park)

• Tax NO.:

  91110000103044655Y

• Registered Funds:

  200 million yuan

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