Cephalexin and Trimethoprim Capsules

Cephalexin is a first-generation cephalosporin with an antibacterial spectrum similar to that of cephalothin, but its antibacterial activity is poorer than that of the latter. Except for Enterococcus and methicillin-resistant Staphylococci, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and Staphylococci that produce or do not produce penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product. This product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are moderately sensitive to this product. Trimethoprim is an antibacterial agent, and its mechanism of action is to interfere with bacterial folate metabolism.

This product is a compound preparation, each tablet containing 0.125g of cephalexin and 0.025g of trimethoprim.

This product is a capsule, and the contents are white or off-white granules and powder.

Used for infections caused by penicillin-resistant Staphylococci, Streptococci, Pneumococci, Escherichia coli, etc.

Oral administration: 1~2 capsules at a time, 4 times a day. Children can take a smaller dose or follow the doctor's advice.

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever. Rarely, anaphylactic shock may occur. 3. Neurological reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4. Renal damage may occur occasionally during the use of this product. 5. Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported. 6. Trimethoprim's interference with folic acid metabolism can produce adverse reactions in the blood system, such as leukopenia, thrombocytopenia or methemoglobin anemia. Generally, leukopenia and thrombocytopenia are mild, and can be recovered by stopping the drug in time. Folic acid preparations can also be added.

1. Patients who are allergic to cephalosporins or penicillin are prohibited from using this product. 2. Patients who are allergic to trimethoprim are prohibited from using this product. 3. Neonates and premature infants are prohibited from using this product. 4. Patients with severe liver and kidney diseases are prohibited from using this product. 5. Patients with blood diseases are prohibited from using this product.

Precautions for children: Not for use in newborns and premature infants. Precautions for pregnancy and lactation: Not for use in newborns and premature infants. Precautions for the elderly: Not yet clear.

1. When used in combination with cholestyramine, the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the renal excretion of this product, and there are also reports that probenecid can increase the excretion of this product in bile. 3. When bone marrow suppressants are used in combination with this product, the chance of leukopenia and thrombocytopenia increases.

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Cephalexin 62.5 mg, trimethoprim 12.5 mg

Tentative 24 months