Sulbactam Sodium for Injection

This product is a semi-synthetic β-lactamase inhibitor, which has strong antibacterial activity against Neisseria gonorrhoeae, Neisseria meningitidis and Acinetobacter calcoaceticus, and has poor effects on other bacteria, but has strong irreversible competitive inhibition of β-lactamase produced by Staphylococcus aureus and most Gram-negative bacteria. When used in combination with penicillins and cephalosporins, it can reduce the MIC of Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, etc., which are resistant to the first two types of antibiotics due to enzyme production, to within the sensitive range. This product has a strong affinity for PBP1 of Bacillus mirabilis and PBP2 of Acinetobacter calcoaceticus.

Sulbactam sodium

This product is white or off-white crystalline powder.

This product is used in combination with ampicillin to treat urinary tract infections, lung infections, bronchial infections, ENT infections, abdominal and pelvic infections, biliary tract infections, sepsis, skin and soft tissue infections, etc. caused by sensitive bacteria.

When this product is used with ampicillin at a dosage ratio of 1:2: for general infections, the adult dosage is 1-2g sulbactam and 2-4g ampicillin per day, divided into 2-3 intravenous drips or intramuscular injections; for mild infections, 0.5g sulbactam and 1g ampicillin per day, divided into 2 intravenous drips or intramuscular injections; for severe infections, the dosage can be increased to 3-4g sulbactam and 6-8g ampicillin per day, divided into 3-4 intravenous drips. The maximum dosage of sulbactam does not exceed 4g per day.

The incidence of adverse reactions of this product combined with ampicillin is about 10% or less, and only 0.7% of patients need to stop treatment. The incidence of pain at the injection site is about 3.6%, and reactions such as phlebitis, diarrhea, and nausea occasionally occur. The incidence of rash is 1% to 6%. Occasionally, transient eosinophilia and elevated serum aminotransferase are seen. Exfoliative dermatitis and anaphylactic shock occur in very rare cases.

When used in combination with penicillins, it is contraindicated for patients who are allergic to penicillins.

1. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product from the kidneys. Therefore, when used in combination with this product, the blood concentration of the drug will increase, the excretion time will be prolonged, and the toxicity may also increase. 2. This product should not be used in combination with disulfiram (an acetaldehyde dehydrogenase inhibitor).

Sealed, stored in a cool and dry place. Validity period: 24 months

0.5g (calculated as C8H11NO5S)

Germany Pharmaceutical Co., Ltd.

• Founded in:

  2010-12-06

• Address:

  No. 216, East Section of Ping'an Avenue, Xiangcheng City, Henan Province

• Tax NO.:

  914116005664681555

• Registered Funds:

  55 million yuan

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