Metacycline Hydrochloride Tablets

Tetracycline antibiotics. This product is a broad-spectrum antibacterial agent. Many Rickettsia, Mycoplasma, Chlamydia, and Spirochete are sensitive to this product. Enterococci are resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are also sensitive to this product. Due to the widespread use of oxytetracycline and tetracyclines over the years, common clinical pathogens have serious resistance to oxytetracycline, including Gram-positive bacteria such as Staphylococcus and most Gram-negative bacteria. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of the peptide chain and affect the synthesis of bacterial proteins.

The main ingredient of this product is metacycline hydrochloride, and its chemical name is [4S-(4alpha;,4aalpha;,5alpha;,5aalpha;,12aalpha;)]-6-methylene-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride

This product is a sugar-coated tablet or a film-coated tablet, which appears yellow or khaki after removing the coating.

1. This product can be used as the first choice or optional drug for the following diseases: (1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever. (2) Mycoplasma infections. (3) Chlamydia infections, including psittacosis, lymphogranuloma venereum, non-gonococcal urethritis, salpingitis, cervicitis and trachoma. (4) Relapsing fever. (5) Brucellosis. (6) Cholera. (7) Tularemia. (8) Plague. (9) Chancroid. It should be used in combination with aminoglycosides to treat brucellosis and plague. 2. Due to the serious resistance of common pathogens to tetracyclines, this type of drug is only indicated when the pathogens are sensitive to this type of drug. This product should not be used for hemolytic streptococcal infections and staphylococcal infections. 3. This product can be used for tetanus, gas gangrene, yaws, syphilis, gonococcal urethritis, cervicitis and leptospirosis, as well as actinomycetes and listeria infections in patients who are allergic to penicillins. 4. It can be used as an adjuvant treatment for moderate to severe acne.

Oral administration: 1.5-2g per day for adults, divided into 3-4 times; 30-40mg/kg per day for children over 8 years old, divided into 3-4 times. This product is contraindicated for children under 8 years old.

1. Digestive system: Gastrointestinal symptoms such as nausea, vomiting, upper abdominal discomfort, abdominal distension, diarrhea, and occasionally pancreatitis. Occasionally, there are reports of esophagitis and esophageal ulcers, which mostly occur in patients who go to bed immediately after taking the medicine. 2. Hepatotoxicity: Usually fatty liver degeneration, which is prone to occur in pregnant women and patients with original renal impairment, and can also occur in patients without the above conditions. Pancreatitis caused by this product can also occur simultaneously with hepatotoxicity, and the patient does not have primary liver disease. 3. Allergic reactions: Mostly maculopapular rash and erythema, in addition to urticaria, angioneurotic edema, allergic purpura, pericarditis, and aggravation of systemic lupus erythematosus skin lesions can be seen, and epidermal exfoliative dermatitis is not common. Occasionally, anaphylactic shock and asthma occur. Some patients who use this product may have photosensitivity when exposed to the sun. Therefore, it is recommended that patients should not be exposed directly to sunlight or ultraviolet rays, and the drug should be stopped immediately if erythema appears on the skin. 4 Blood system: Occasionally it may cause hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia. 5 Central nervous system: Occasionally it may cause benign intracranial hypertension, which may manifest as headache, vomiting, papilledema, etc. 6 Nephrotoxicity: Patients with significant renal impairment may develop azotemia, hyperphosphatemia and acidosis. 7 Dual infection: Long-term use of this product may induce secondary infection caused by drug-resistant Staphylococcus aureus, Gram-negative bacilli and fungi, and in severe cases may cause sepsis. 8 This product can be deposited in teeth and bones, causing varying degrees of discoloration and yellowing of teeth, enamel hypoplasia and caries, and can also cause skeletal dysplasia. 9 The use of this product can reduce the normal flora in the human body, leading to vitamin B deficiency, fungal reproduction, dry mouth, sore throat, angular cheilitis and glossitis, etc.

Patients with a history of allergy to tetracyclines are contraindicated.

Precautions for children: This product should not be used in children under 8 years old. Precautions for pregnancy and lactation: This product can enter the fetus through the placental barrier and deposit in the calcium area of teeth and bones, causing fetal tooth discoloration, poor enamel regeneration and inhibition of fetal bone growth. This type of drug has teratogenic effects in animals, so it should not be used by pregnant women. This product can be secreted from breast milk, and the concentration in breast milk is relatively high. When using it, breastfeeding women should suspend breastfeeding. Precautions for the elderly: Elderly patients are often accompanied by renal impairment, and the dosage should be adjusted appropriately. Elderly patients using this product are prone to hepatotoxicity and should be used with caution.

1. When used with antacids such as sodium bicarbonate, the absorption of this product will be reduced and its activity will be reduced due to the increase in the pH value in the stomach. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2. Drugs containing metal ions such as calcium, magnesium, and iron can form insoluble complexes with this product, reducing the absorption of this product after oral administration. 3. When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity can be enhanced. 4. When used in combination with strong diuretics such as furosemide, renal damage can be aggravated. 5. When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage can be aggravated. 6. The lipid-lowering drugs colestyramine or colestipol can affect the absorption of this product, and must be taken separately for several hours. 7. This product can reduce the effect of contraceptives and increase the possibility of extramenstrual bleeding. 8. This product can inhibit the activity of plasma prothrombin, so patients receiving anticoagulant therapy need to adjust the dose of anticoagulants.

Keep in a dark place, sealed and protected from light

0.1g (calculated as C22H22N2O8)

24 months