Ceftriaxone Sodium

Ceftriaxone sodium is a broad-spectrum third-generation cephalosporin with a low MIC, very stable to beta-lactamase, widely distributed in body fluids and various organs, with few side effects and good stability. It has strong antibacterial activity against Enterobacteriaceae, and both influenza bacilli and gonococci that produce and do not produce beta-lactamase are highly sensitive to this product. It has stronger antibacterial effects on Escherichia coli, aerogenes, various Proteus species and influenza bacilli than second-generation cephalosporins. It has stronger activity against gram-positive cocci such as hemolytic streptococci and pneumococci.

The main component of this product is cefotaxime sodium, and its chemical name is (6R, 7R)-3-[(acetyloxy)methyl]-7-[(2-amino-4-thiazolyl)-(methoxyimino)acetylamino]-8-oxo-5-thia-1-azacyclo[4,2,0]oct-2-ene-2-carboxylate sodium. The molecular formula is C16H16N5NaO7S2, and the molecular weight is 477.45.

It is suitable for pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, sepsis, abdominal infections, pelvic infections, skin and soft tissue infections, reproductive tract infections, bone and joint infections caused by sensitive bacteria. Cefotaxime can be used as a drug of choice for pediatric meningitis.

Intramuscular or intravenous injection, adults, moderate infection, 1g/time, 1 time/12 hours; severe infection, more serious drug allergy, more serious drug allergy, 8g~12g/day, divided into 3~4 times; children 100mg~150mg/kg per day, divided into 2~4 times; newborns 50mg/kg per day, divided into 2~4 times. This product can also be used for intravenous drip, preferably 1g~2g dissolved in normal saline or glucose injection solution for dilution, and the drip is completed within 20~60 minutes.

The incidence of side effects is low, about 3-5%, rash and drug fever are about 2-5%, phlebitis, diarrhea, nausea, vomiting, loss of appetite and other digestive tract reactions are seen in 1% of patients, alkaline phosphatase or serum transaminase slightly elevated in about 3%, temporary blood urea nitrogen and creatinine increased in 0.7% and 0.3% respectively, leukopenia, acidosis or thrombocytopenia are rare. Occasionally headache, numbness, dyspnea and facial flushing occur. After using this product, 0.28% of patients may develop mucosal candidiasis.

1. When using this product, breastfeeding should be stopped. This product can pass through the blood-placental barrier and enter the fetal blood circulation. Pregnant women should only use it for patients with definite indications; 2. Infants and young children should not be given intramuscular injections.

1. It has a synergistic effect with gentamicin or tobramycin against Pseudomonas aeruginosa; it has a synergistic effect with amikacin against Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. 2. When used in combination with aminoglycoside antibiotics, renal function should be followed up during medication. 3. When large doses of cefotaxime are used in combination with strong diuretics, attention should be paid to changes in renal function. 4. Cefotaxime can be diluted with sodium chloride injection or glucose solution, but cannot be mixed with sodium bicarbonate solution. 5. When used in combination with azlocillin or mezlocillin, the total clearance rate of this product can be reduced. If the two are used in combination, the dose should be appropriately reduced.

Keep tightly closed in a cool, dark and dry place.

Harbin HEJIA Pharmaceutical Co., Ltd.

• Founded in:

  1995-05-26

• Address:

  Shangzhi Economic and Technological Development Zone

• Tax NO.:

  91230183744159225H

• Registered Funds:

  65.5 million yuan

• Email:

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