Oxacillin Sodium for Injection

This product is an acid-resistant and penicillinase-resistant penicillin. It has good antibacterial activity against penicillinase-producing Staphylococci, but its antibacterial activity against various streptococci and non-penicillinase-producing Staphylococci is inferior to penicillin G. This product exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

The main ingredient of this product is oxacillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate.

This product is white powder or crystalline powder.

This product is mainly used for various infections caused by penicillin-resistant Staphylococcus, including sepsis, respiratory tract infection, meningitis, soft tissue infection, etc. It can also be used for mixed infections caused by Streptococcus pyogenes or Pneumococcus and penicillin-resistant Staphylococcus.

1 For intramuscular injection, add 2.8ml of sterile water for injection for every 0.5g. For intramuscular injection, adults take 4-6g per day, divided into 4 doses; for intravenous drip, adults take 4-8g per day, divided into 2-4 doses. For severe infection, the daily dose can be increased to 12g. 2 For children weighing less than 40kg, give 12.5-25mg/kg every 6 hours according to body weight, and for those weighing more than 40kg, give adult doses. For newborns weighing less than 2kg, give 25mg/kg every 12 hours for those aged 1-14 days, and 25mg/kg every 8 hours for those aged 15-30 days; for those weighing more than 2kg, give 25mg/kg every 8 hours for those aged 1-14 days, and 25mg/kg every 6 hours for those aged 15-30 days. 3 Patients with mild and moderate renal impairment do not need to adjust the dose. Patients with severe renal impairment should avoid using large doses to prevent central nervous system toxicity.

1. Allergic reaction: urticaria and other types of rashes are common, leukopenia, interstitial nephritis, asthma attacks and serum sickness reactions are rare; anaphylactic shock is occasionally seen. Once it occurs, it must be rescued on the spot, and treatment measures such as keeping the airway open, oxygen inhalation, and the use of epinephrine and glucocorticoids are given. 2. Intravenous use of this product may occasionally cause nausea, vomiting and elevated serum aminotransferase. 3. Large doses of intravenous infusion of this product may cause convulsions and other central nervous system toxic reactions. 4. There are reports of infants developing hematuria, proteinuria and uremia after using large doses of this product.

It is contraindicated in patients with a history of allergy to penicillins or a positive penicillin skin test.

1. This product is incompatible with aminoglycosides, norepinephrine, metahydroxylamine, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of oxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides can inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.

Keep tightly closed in a dry place.

0.5g (calculated as C19H19N3O5S)

Guangzhou Baiyunshan Tianxin Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-28

• Address:

  No. 808, Binjiang East Road, Haizhu District, Guangzhou

• Tax NO.:

  91440101190485108B

• Registered Funds:

  45.693 million yuan

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