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Sodium oxacillin monohydrate

Sodium oxacillin monohydrate structure

CAS No:
7240-38-2
Formula:
C19H19N3O5S.H2O.Na
Chemical Name:
Sodium oxacillin monohydrate
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-,sodium salt,hydrate (1:1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-,monosodium salt,monohydrate;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-,monosodium salt,monohydrate,[2S-(2α,5α,6β)]-;Sodium oxacillin monohydrate;Stapenor sodium;Oxacillin sodium hydrate
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Oxacillin sodium monohydrate is an antibiotic similar to flucloxacillin used in resistant staphylococci infections.Target: AntibacterialOxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Another related compound is nafcillin. Since it is resistant to penicillinase enzymes, such as that produced by Staphylococcus aureus, it is widely used clinically in the US to treat penicillin-resistant Staphylococcus aureus. Howe

Sodium oxacillin monohydrate Basic Attributes

Molecular Weight：

423.42

Exact Mass：

441.097051 g/mol

EC Number：

214-636-3

DSSTox ID：

DTXSID50273924

HScode：

3004101900

Characteristics

PSA：

142 Å²

XLogP3：

0.99210

Appearance：

white crystalline powd

Melting Point：

188 °C (decomp)

Boiling Point：

687℃

Flash Point：

>110°(230°F)

Refractive Index：

205 ° (C=1, H2O)

Water Solubility：

Freely soluble in water

Storage Conditions：

Refrigerator

Toxicity：

LD50 orally in rats: >8000 mg/kg (Goldenthal)

Specific rotation：

D20 +201° (c = 1 in water)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

22-26-36/37

Marks：

Xn,Xi

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

GHS Classification：

|Danger|H315 (57.75%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 71 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Sodium oxacillin monohydrate Use and Manufacturing

Methods of Manufacturing

It is obtained by condensation of 6-aminopenicillanic acid and benzyl isoxazole acid chloride to form a salt.

Uses

Semi-synthetic acid and enzyme resistant penicillin. Clinically mainly used for drug-resistant Staphylococcus aureus infections, such as sepsis, pneumonia, suppurative meningitis and osteomyelitis.

Computed Properties

Molecular Weight:442.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:442.10487585
Monoisotopic Mass:442.10487585
Topological Polar Surface Area:139
Heavy Atom Count:30
Complexity:681
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an acid-resistant and penicillinase-resistant penicillin, which has good antibacterial activity against penicillinase-producing Staphylococci, but its antibacterial activity against various streptococci and non-penicillinase-producing Staphylococci is inferior to penicillin G. This product exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Oxacillin Sodium for Injection
Ingredients	The main ingredient of this product is oxacillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate.
Indication	1. This product is incompatible with aminoglycosides, norepinephrine, metahydroxylamine, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of oxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides can inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.
Specifications	0.5g (calculated as C19H19N3O5S)
Manufacturer	Guangzhou Baiyunshan Tianxin Pharmaceutical Co., Ltd.

Oxacillin Sodium for Injection
Ingredients	Oxacillin sodium. Its chemical name is: (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate. Molecular formula: C19H18N3Na05Sbull;H20. Molecular weight: 441.44
Indication	1. This product is incompatible with aminoglycosides, norepinephrine, metahydroxylamine, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of oxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides can inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.
Specifications	2.0 g
Manufacturer	Sichuan Pharmaceutical, Inc.

Oxacillin Sodium for Injection
Ingredients	The main ingredient of this product is oxacillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt monohydrate.
Indication	1. This product is incompatible with aminoglycosides, norepinephrine, metahydroxylamine, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of oxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides can inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.
Specifications	Calculated as C19H19N3O5S 0.5g
Manufacturer	Tianjin Huajin Pharmaceutcial Co., Ltd.

See More Related Drugs

Registered Holders

Reyoung Pharmaceutical Co., Ltd.

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Guide of Sodium oxacillin monohydrate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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