Cephalexin and Trimethoprim Granules

Cephalexin is a first-generation cephalosporin with an antibacterial spectrum similar to that of cephalothin, but its antibacterial activity is poorer than that of the latter. Except for Enterococcus and methicillin-resistant Staphylococci, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and Staphylococci that produce or do not produce penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product. This product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are moderately sensitive to this product. Trimethoprim is an antibacterial agent, and its mechanism of action is to interfere with bacterial folate metabolism.

This product is a compound preparation, containing 50 mg of cephalexin and 10 mg of trimethoprim per gram.

This product is a granule with flavoring agent added and has a sweet taste.

Used for infections caused by penicillin-resistant Staphylococci, Streptococci, Pneumococci, Escherichia coli, etc.

Oral administration: 2.5-5.0g (1-2 bags) each time, 4 times a day. For children, the dosage may be reduced or as directed by the doctor.

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever. Rarely, anaphylactic shock may occur. 3. Neurological reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4. Renal damage may occur occasionally during the use of this product. 5. Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported. 6. Trimethoprim's interference with folic acid metabolism can produce adverse reactions in the blood system, such as leukopenia, thrombocytopenia or methemoglobin anemia. Generally, leukopenia and thrombocytopenia are mild, and can be recovered by stopping the drug in time. Folic acid preparations can also be added.

Contraindicated in patients allergic to this product or cephalosporins

Precautions for children: Not for use in newborns and premature infants. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Not yet clear.

1. When used in combination with cholestyramine (cholestyramine), the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the renal excretion of this product, and there are also reports that probenecid can increase the excretion of this product in bile. 3. The chance of leukopenia and thrombocytopenia increases when bone marrow suppressants are used in combination with this product. 4. This product should not be used simultaneously with the anti-tumor drug 2,4-diaminopyrimidine drugs, nor should it be used between courses of treatment with other folic acid antagonists, because it may cause bone marrow hypoplasia or megaloblastic anemia. 5. Co-use of cyclosporine can increase renal toxicity.

seal.

Each gram contains 50mg of cephalexin and 10mg of trimethoprim

24 months

Guizhou Shenqi Pharmaceutical Co., Ltd.

• Founded in:

  2002-02-28

• Address:

  No. 177, Chuangbei Road, Shawen Ecological Technology Industrial Park, Guiyang National High-tech Industrial Development Zone, Guiyang City, Guizhou Province

• Tax NO.:

  91520000736602733A

• Registered Funds:

  138.71 million yuan

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