Prednisolone Acetate Injection

This product is a drug of adrenal cortex hormone. It has multiple pharmacological effects such as anti-inflammatory, anti-allergic and immunosuppressive. 1 Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the manifestation of inflammation. 2 Immunosuppressive effect: prevent or inhibit cell-mediated immune response, delayed allergic reaction, and reduce the expansion of primary immune response. 3 Anti-toxic and anti-shock effect: Glucocorticoids can counteract the stimulation of bacterial endotoxins on the body, reduce cell damage, and play a role in protecting the body; they are also commonly used in clinical treatment of severe shock, especially toxic shock.

Prednisolone acetate. Chemical name: 11,17,21-trihydroxypregna-1,4-diene-3,20-dione-21-acetate.

This product is a suspension of fine particles. The fine particles sink after standing and become a uniform milky white suspension after shaking.

It is mainly used for allergic and autoimmune inflammatory diseases. It is now used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, nephrotic syndrome, thrombocytopenic purpura, granulocytopenia, various adrenal insufficiency, severe dermatitis, acute leukemia, etc. It is also used for the comprehensive treatment of certain infections.

Intramuscular or intra-articular injection: 10-40 mg per day, the dose can be increased if necessary.

There are no obvious adverse reactions when glucocorticoids are used for replacement therapy with physiological doses. Adverse reactions mostly occur when the pharmacological dose is used, and are closely related to the course of treatment, dose, type of medication, usage and route of administration. For example, the systemic adverse reactions caused by intra-articular injection of this product are relatively few and mild. Common adverse reactions are as follows: 1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome face and posture, weight gain, lower limb edema, purple lines, bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, long bone pathological fractures), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and aggravation of diabetes. 2. Patients may experience mental symptoms: euphoria, agitation, delirium, restlessness, disorientation, and may also be manifested as inhibition. Mental symptoms are more likely to occur in people with chronic wasting diseases and those who have had mental disorders in the past. 3. Concurrent infection is the main adverse reaction of adrenocortical hormones. Fungi, tuberculosis, staphylococcus, Proteus, Pseudomonas aeruginosa and various herpes viruses are the main ones. 4. Glucocorticoid withdrawal syndrome. Sometimes patients experience dizziness, fainting tendency, abdominal pain or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. If careful examination can rule out adrenocortical insufficiency and recurrence of the original disease, it can be considered as a syndrome of dependence on glucocorticoids.

It is contraindicated for patients who are allergic to this product and steroid hormone drugs. It is generally not suitable for patients with the following diseases. In special circumstances, the pros and cons should be weighed and attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, trauma repair period, corneal ulcer, hyperadrenocorticism, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibiotics such as chickenpox, measles, fungal infections, severe osteoporosis, etc.

1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by it. 7. When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. 10. When used in combination with cardiac glycosides, it can increase the occurrence of digitalis toxicity and arrhythmia. 11 When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12 When used in combination with ephedrine, its metabolic clearance can be enhanced. 13 When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14 It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15 It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16 When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17 When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

seal.

5ml:0.125g

18 months

Shanghai CP GENERAL Pharmaceutical Co., Ltd.

• Founded in:

  2000-11-20

• Address:

  No. 889, Shennan Road, Minhang District, Shanghai

• Tax NO.:

  913100007030684906

• Registered Funds:

  107.37 million yuan

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