Lidocaine Hydrochloride Injection

This product is an amide local anesthetic. After blood absorption or intravenous administration, it has obvious biphasic effects of excitation and inhibition on the central nervous system, and there may be no precursor excitation. When the blood concentration is low, analgesia and drowsiness occur, and the pain threshold increases; with increasing doses, the effect or toxicity increases, and there is an anticonvulsant effect at sub-toxic blood concentrations; when the blood concentration exceeds 5mu; gml-1, convulsions may occur. At low doses, this product can promote the outflow of potassium in myocardial cells, reduce the autonomy of the myocardium, and have an anti-ventricular arrhythmia effect; at therapeutic doses, it has no obvious effect on the electrical activity of myocardial cells, atrioventricular conduction, and myocardial contraction; further increases in blood concentrations can cause a slowing of cardiac conduction velocity, atrioventricular conduction block, inhibition of myocardial contractility, and a decrease in cardiac output.

The main ingredient of this product: lidocaine hydrochloride. Its chemical name is: N-(dichloroxylyl)-2-(diethylamino)acetamide hydrochloride monohydrate. Molecular formula: C14H22N20·HCl·H20 Molecular weight: 288.82

This product is a local anesthetic and antiarrhythmic drug. It is mainly used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction block. This product can also be used for ventricular premature beats and ventricular tachycardia after acute myocardial infarction, and can also be used for ventricular arrhythmias caused by digitalis poisoning, cardiac surgery and cardiac catheterization. This product is usually ineffective for supraventricular arrhythmias.

1. For anesthesia (1) Common dosage for adults: ① Surface anesthesia: 2% to 4% solution, not more than 100 mg at a time. When injecting, the single dose should not exceed 4.5 mg/kg (without epinephrine) or 7 mg/kg per dose (with epinephrine at a concentration of 1:200000). ② Sacral block for labor analgesia: use 1.0% solution, limited to 200 mg. ③ Epidural block: use 1.5% to 2.0% solution for thoracolumbar segment, 250 to 300 mg. ④ Infiltration anesthesia or intravenous regional block: use 0.25% to 0.5% solution, 50 to 300 mg. ⑤ Peripheral nerve block: brachial plexus (unilateral) with 1.5% solution, 250-300mg; dental 2% solution, 20-100mg; intercostal nerve (each branch) with 1% solution, 30mg, 300mg as the limit; paracervical infiltration with 0.5%-1.0% solution, 100mg on each side; paravertebral spinal nerve block (each branch) with 1.0% solution, 30-50mg, 300mg as the limit; pudendal nerve with 0.5%-1.0% solution, 100mg on each side. ⑥ Sympathetic ganglion block: cervical stellate nerve with 1.0% solution, 50mg; spinal anesthesia with 1.0% solution, 50-100mg. ⑦ The single dose is 200 mg (4 mg/kg) without adrenaline, and 300-350 mg (6 mg/kg) with adrenaline; the maximum dose for intravenous regional blockade is 4 mg/kg; the first dose for intravenous treatment is 1-2 mg/kg, the maximum dose is 4 mg/kg, and the intravenous drip for adults is limited to 1 mg per minute; repeated administration, the interval time should not be shorter than 45-60 minutes. (2) The common dosage for children varies with the individual, and the total amount of a single dose should not exceed 4.0-4.5 mg/kg. 0.25%-0.5% solution is commonly used, and 1.0% solution is used only in special circumstances. 2. Antiarrhythmic: (1) Common dosage ① Intravenous injection of 1-1.5 mg/kg body weight (generally 50-100 mg) as the first loading dose intravenously for 2-3 minutes, if necessary, repeat the intravenous injection 1-2 times every 5 minutes, but the total amount within 1 hour should not exceed 300 mg. ② Intravenous drip is generally made of 5% glucose injection to make a 1-4 mg/ml solution for drip or administration with an infusion pump. After the loading dose, it can be maintained by intravenous drip at a rate of 1-4 mg per minute, or intravenous drip at a rate of 0.015-0.03 mg/kg body weight per minute. The dosage should be reduced in the elderly, heart failure, cardiogenic shock, reduced liver blood flow, liver or kidney dysfunction. Drip at 0.5-1 mg per minute. You can use 0.1% solution of this product for intravenous drip, not more than 100 mg per hour. (2) Maximum intravenous injection within 1 hour The maximum loading dose is 4.5 mg/kg body weight (or 300 mg) and the maximum maintenance dose is 4 mg per minute.

1. This product can act on the central nervous system, causing adverse reactions such as drowsiness, paresthesia, muscle tremor, convulsion, coma and respiratory depression. 2. It can cause hypotension and bradycardia. If the blood concentration is too high, it can cause atrial conduction velocity slowing, atrioventricular conduction block, inhibition of myocardial contractility and decreased cardiac output.

1. Patients who are allergic to local anesthetics are contraindicated. 2. Patients with Adams-Stokes syndrome (acute cardiogenic cerebral ischemic syndrome), preexcitation syndrome, and severe heart block (including sinoatrial, atrioventricular, and intraventricular block) are contraindicated for intravenous administration.

Precautions for children: The drug may cause poisoning in neonates, and the half-life of premature infants is longer than that of normal infants (3.16 hours: 1.8 hours). Precautions for pregnancy and lactation: This product crosses the placenta and binds to fetal proteins more than adults. Precautions for the elderly: The dosage should be adjusted according to the needs and tolerance of the elderly. The dosage should be halved for patients over 70 years old.

1. When used in combination with cimetidine and beta-receptor blockers such as propranolol, metoprolol, and nadolol, lidocaine metabolism in the liver is inhibited, lidocaine blood concentration increases, and adverse reactions to the heart and nervous system may occur. The lidocaine dose should be adjusted, and electrocardiogram monitoring and lidocaine blood concentration should be performed. 2. It is contraindicated with the following drugs: amphotericin B, ampicillin, methohexital, and sulfadiazine.

Keep tightly closed.

5ml:0.1g

Shandong Shenglu Pharmaceutical Co., Ltd.

• Founded in:

  2001-12-27

• Address:

  North end of Sihe Road, Sihe Office, Sishui County

• Tax NO.:

  91370831678104460B

• Registered Funds:

  1.2 million yuan

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