Racemic Anisodamine Hydrochloride Injection

[Pharmacology and Toxicology] It has a peripheral anti-M cholinergic receptor effect, can relieve smooth muscle spasm caused by acetylcholine, can also relieve microvascular spasm, and improve microcirculation. It has a relaxing effect on gastrointestinal smooth muscle and inhibits its peristalsis. Its effect is slightly weaker than atropine, and its effect on inhibiting the secretion of digestive glands is 1/10 of atropine. The effect of inhibiting salivary gland secretion and dilating pupils is weaker, which is 1/20 to 1/10 of atropine. Because it is not easy to pass through the blood-cerebrospinal fluid barrier, its central effect is also weaker than atropine. [Pharmacokinetics] 15 minutes after intravenous injection in rats, the concentration in the kidney is the highest, 30 minutes after the pancreas is high, followed by the kidney, heart, lung, spleen, liver, and low concentration in the brain and plasma. It takes effect 1 to 2 minutes after intravenous injection and is quickly excreted from the kidney, with a T1/2 of about 40 minutes. There is no accumulation effect in long-term use.

The main ingredient of this product is: racemic anisodamine hydrochloride. Its chemical name is: (±)-6β-hydroxy-1αH, 5αH-tropane-3α-ol tropate hydrochloride.

This product is a colorless clear liquid.

Anti-M cholinergic drugs are mainly used to relieve smooth muscle spasms, gastrointestinal colic, biliary spasm, acute microcirculatory disorders and organophosphorus poisoning.

1. Common dosage: 5-10 mg for adults, 0.1-0.2 mg/kg for children, 1-2 times a day. 2. Anti-shock and organophosphorus poisoning: intravenous injection, 10-40 mg for adults, 0.3-2 mg/kg for children, if necessary, repeat the administration every 10-30 minutes, or increase the dosage. After the condition improves, the dosing interval should be gradually extended until the drug is stopped.

Common symptoms include dry mouth, flushed face, blurred vision, etc.; rare symptoms include rapid heartbeat, difficulty urinating, etc. The above symptoms usually disappear within 1-3 hours. Atropine-like poisoning symptoms may occur when the dosage is too large.

It is contraindicated for patients with increased intracranial pressure, acute cerebral hemorrhage, glaucoma, pyloric obstruction, intestinal obstruction and prostatic hypertrophy; it should be used with caution in patients with reflux esophagitis and severe ulcerative colitis.

Precautions for children: Use with caution in infants and young children. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Use with caution in the elderly and weak: Elderly men often suffer from prostate hypertrophy, which can easily lead to prostate congestion and urinary retention after taking the drug.

1. When used in combination with amantadine, phenothiazines, tricyclic antidepressants, primidone, procainamide and other anticholinergic drugs, adverse reactions may increase. 2. When used in combination with monoamine oxidase preparations (including furazolidone and procarbazine), the side effects of antimuscarinic effects may be enhanced. 3. It can weaken gastrointestinal motility and delay gastric emptying, affecting some drugs, such as erythromycin staying in the stomach for too long, reducing the efficacy, delaying the absorption of acetaminophen, and increasing the absorption of digoxin, nitrofurantoin and other drugs.

Keep tightly closed.

1ml:10mg

24 months

Zhengzhou Zhuofeng Pharmaceutical Co., Ltd.

• Founded in:

  2008-10-27

• Address:

  North side of Renmin East Road, Xinzheng City

• Tax NO.:

  91410184170459631H

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  10 million yuan

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