Isosorbide Mononitrate Sodium Chloride Injection
Function and Efficacy
Isosorbide mononitrate is the main active metabolite of isosorbide nitrate in the body. It can dilate peripheral blood vessels, especially increase venous blood volume, reduce venous return, reduce cardiac preload and afterload, thereby reducing myocardial oxygen consumption; at the same time, it can also improve blood supply to the ischemic area by promoting myocardial blood flow redistribution, and may play an anti-myocardial ischemic role through these two aspects. The LD50 (mg/kg) of intravenous injection of isosorbide mononitrate is: 2250 (female) and 1820 (male) in mice; 1750 (female) and 1880 (male) in rats.
Ingredients
Ingredients: Injection: isosorbide mononitrate 20 mg, sodium chloride NaCl 2.25 g, chemical name: 1,4:3,6-dianhydro-D-sorbitol-5-mononitrate and sodium chloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Isosorbide 5-mononitrateIngredients |
It can dilate peripheral blood vessels, especially increase venous blood volume, reduce the amount of blood returning to the heart, reduce the preload and postload of the heart, and thus reduce myocardial oxygen consumption; at the same time, it can also improve the blood supply to the ischemic area by promoting the redistribution of myocardial blood flow, and may exert its anti-myocardial ischemia effect through these two aspects. More |
16051-77-7 | 23 | |
| Sodium chlorideExcipients |
Isosorbide mononitrate is the main active metabolite of isosorbide nitrate in the body. It can dilate peripheral blood vessels, especially increase venous blood volume, reduce venous return, reduce cardiac preload and afterload, thereby reducing myocardial oxygen consumption; at the same time, it can also improve blood supply to the ischemic area by promoting myocardial blood flow redistribution, and may play an anti-myocardial ischemic role through these two aspects. The LD50 (mg/kg) of intravenous injection of isosorbide mononitrate is: 2250 (female) and 1820 (male) in mice; 1750 (female) and 1880 (male) in rats. More |
7647-14-5 | 43 |
Appearance
This product is a colorless clear liquid.
Indication
Vasodilator. Suitable for the treatment of angina pectoris and congestive heart failure.
Usage and Dosage
Intravenous drip. The drug dosage can be adjusted according to the patient's response. The general effective dose is 2-7 mg per hour. The starting dose is 60 μg/min, and the general dose is 60-120 μg/min, once a day, 20 mg each time, and 10 days as a course of treatment.
Adverse Reactions
Like other nitrate drugs, during use, especially in the early stages of administration, symptoms such as headache and nausea may occur due to vasodilation. 1. Common symptoms include: dizziness, fainting, and flushing of the cheeks and neck caused by postural hypotension; in severe cases, persistent headaches, nausea, vomiting, tachycardia, and irritability may occur; rashes, blurred vision, and dry mouth are rare. 2. Clinical manifestations of overdose: In order of incidence, they are: bluish lips and nails, dizziness, head swelling, shortness of breath, extreme fatigue, fast and weak heartbeat, fever, and even convulsions.
Precautions
It is contraindicated in patients with glaucoma, anemia, head trauma, cerebral hemorrhage, severe hypotension or hypovolemia, and those who are sensitive to this product or nitrates.
Special Population Medication
Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Unless the doctor deems it necessary, this product should not be used in pregnant and lactating women. Precautions for the elderly: The kidney is the main excretion route, and the side effects of the drug caused by changes in excretion should be closely observed during use.
Drug Interactions
Other vasodilators, especially alcohol, can increase the vasodilator effect of this product. It has been reported that the combination with calcium blockers causes obvious symptoms of postural hypotension, so the dosage should be reduced when used in combination.
Storage
Store at room temperature in a dark place and tightly sealed.
Packaging Specification
100ml: 20mg of isosorbide mononitrate and 0.9g of sodium chloride
Validity Period
24 months
Manufacturer
Lunan BETTER Pharmaceutical Co., Ltd.
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Founded in:
2003-12-16 -
Address:
No. 209, Hongqi Road, Linyi City -
Tax NO.:
91371300756399007K -
Registered Funds:
115 million yuan -
Website:
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Email: