Not yet clear

Not yet clear

Angiotensin II receptor antagonist, selectively acts on AT1 receptor subtype, reduces elevated blood pressure, and does not affect heart rate. A single oral dose produces a hypotensive effect within 2 hours, reaches a peak effect within 4 to 6 hours, and the hypotensive effect is maintained for more than 24 hours after taking the medicine. Long-term treatment reaches the maximum hypotensive effect after 2 to 4 weeks and is maintained. Combined use with hydrochlorothiazide significantly enhances the hypotensive effect. Sudden termination of treatment does not cause hypertension rebound or other side effects. Does not affect fasting total cholesterol, triglycerides, blood sugar or uric acid levels.

Thiazide diuretics act mainly at the proximal end of the distal convoluted tubule, inhibiting sodium and chloride co-transport, increasing sodium and chloride excretion, and indirectly reducing plasma volume. By increasing renin activity, aldosterone secretion, and potassium excretion, serum potassium decreases. Combining them with angiotensin II receptor antagonists can reduce potassium loss.

Selectively inhibit fungal squalene epoxidase, interfere with the biosynthesis of ergosterol in the fungal cell wall, affect the lipid metabolism of the fungus, damage or kill the fungal cells, and play a bactericidal and antibacterial role

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