Ornidazole injection

This product is a third-generation nitroimidazole derivative. The mechanism by which it exerts its antimicrobial effect may be: through the nitro group in its molecule, it is reduced to an amino group in an anaerobic environment or through the formation of free radicals, which interacts with cell components and causes the death of microorganisms.

Ornidazole. The excipient is propylene glycol.

This product is a light yellow-green clear liquid.

1. It is used to treat various infectious diseases caused by sensitive anaerobic bacteria such as Bacteroides fragilis, Bacteroides dissimilar, Bacteroides ovale, Bacteroides thetaiotaomicron, Bacteroides vulgaris, Clostridium, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninus, Fusobacterium, Co2-phagocytosis, Bacteroides gingivalis, etc., including: (1) abdominal infection: peritonitis, intra-abdominal abscess, liver abscess, etc.; (2) pelvic infection: endometritis, myometritis, fallopian tube or ovarian abscess, pelvic soft tissue infection, Haemophilus vaginitis, etc.; (3) oral infection: periodontitis, apical periodontitis, pericoronitis, acute ulcerative gingivitis, etc.; (4) surgical infection: wound infection, epidermal abscess, bedsore ulcer infection, cellulitis, gas gangrene, etc.; (5) brain infection: meningitis

Intravenous drip: Before use, the product must first be appropriately diluted and then intravenously dripped for about 60 minutes. For adults, one or two vials of this product (10ml: 0.5g) must be added to 250ml or 500ml of commonly used clinical infusion (such as 5% glucose, 10% glucose, 0.9% sodium chloride injection), that is, the former contains 0.5g of the main drug, and the latter contains 1.0g of the main drug, and then intravenously dripped. 1. Prevention of postoperative anaerobic infection: 10g intravenous drip before surgery. 2. For the treatment of acute infections related to anaerobic infections in gynecology, surgery and dentistry, the first dose is 0.5-1.0g intravenously dripped, followed by 0.5g every 12 hours for a total of 5-10 days. Children are given 10mg/ every 12 hours.

This product is generally well tolerated. The following reactions may occur during medication: 1. Digestive system: including mild stomach discomfort, stomach pain, bad breath, etc.; 2. Nervous system: including headache and drowsiness, dizziness, tremor, numbness of limbs, cramps and mental confusion, etc.; 3. Allergic reactions: such as rash, itching, etc.; 4. Local reactions: including tingling, pain, etc.; 5. Others: leukopenia, etc.

1. It is contraindicated for patients who are allergic to this product and other nitroimidazole drugs; 2. It is contraindicated for patients with brain and spinal cord lesions, epilepsy and various organ sclerosis; 3. It is contraindicated for patients with low hematopoietic function and chronic alcoholism.

Precautions for children: Use with caution in children. It is not recommended for children under 3 years old. Precautions for pregnancy and lactation: Use with caution in early pregnancy (first three months of pregnancy) and lactating women. Precautions for the elderly: Use the same medication as adults.

1. Compared with other nitroimidazole drugs, this product has no inhibitory effect on acetaldehyde dehydrogenase. 2. Ornidazole can inhibit the metabolism of the anticoagulant warfarin, prolong its half-life, and enhance the efficacy of the anticoagulant. When used with warfarin, attention should be paid to observing the prothrombin time and adjusting the dosage. 3. Barbiturates, ranitidine, cimetidine and other drugs can accelerate the elimination of ornidazole and reduce its efficacy and affect coagulation, so they should be contraindicated for combined use. 4. The simultaneous use of drugs that induce liver microsomal enzymes such as phenytoin sodium and phenobarbital can enhance the metabolism of this product, reduce the blood drug concentration, and slow down the excretion of phenytoin sodium. 5. This product can delay the effect of the muscle relaxant vecuronium bromide.

Keep in a dark and airtight place (10-30℃).

5ml:0.5g

24 months.

Nanjing Sanhome Pharmaceutical Co., Ltd.

• Founded in:

  1996-09-19

• Address:

  No. 9 Huizhong Road, Nanjing Economic and Technological Development Zone

• Tax NO.:

  91320192608959455D

• Registered Funds:

  430 million yuan

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