Ketoconazole tablets

Ketoconazole is a synthetic imidazole dioxane derivative that has antibacterial and bactericidal activity against dermatophytes, yeasts (Candida, Pityrosporum, Torulopsis, Cryptococcus), dimorphic fungi and fungi. Ketoconazole is less sensitive to Aspergillus, Sporothrix schenckii, some dematiaceae, and Mucor, but is an exception to Entomophthorales. Ketoconazole inhibits the biosynthesis of fungal ergosterol and changes the composition of other lipid compounds in the cell membrane. Long-term animal toxicity experiments have shown that this product can significantly increase alkaline phosphatase and degenerate liver cells.

The main chemical component is ketoconazole: 1-acetyl-4[4-[2-(2,4-dichlorophenyl)-2(1H-imidazole-1-methyl)-1,3-dioxolane-4-methoxy]phenyl]-piperazine.

This product is white tablets.

Systemic fungal infections, such as systemic candidiasis, paracoccidioidomycosis, and histoplasmosis. This drug can be used to treat infections of the skin, hair, and nails (dermatophytes, onychomycosis, perionychia, tinea versicolor, chronic skin and mucosal candidiasis, etc.) caused by dermatophytes and/or yeasts when local treatment is ineffective or it is difficult to apply the drug due to factors such as the site, area, and depth of infection. Gastrointestinal yeast infections. Chronic and recurrent vaginal candidiasis that is ineffective with local treatment. Used for the prevention and treatment of patients who are susceptible to fungal infections due to reduced immune function (hereditary and caused by disease or drugs). This product has poor penetration into the central nervous system and is not suitable for the treatment of fungal meningitis.

This product must be used under the guidance of a doctor. Adults: Deep fungal infection: Oral, 1-2 times a day, 1 tablet (200 mg) each time. Skin infection: Oral, 1 tablet (200 mg) once a day, taken with meals. If necessary, it can be increased to 1 time a day, 2 tablets (400 mg) each time, or 2 times a day, 1 tablet (200 mg) each time. Vaginal candidiasis: Oral, 1 time a day, 2 tablets (400 mg) each time, taken with meals. Children: Deep fungal infection: Oral, 4-8 mg per kilogram of body weight per day. Skin infection: Children weighing less than 15 kg, 3 times a day, 20 mg each time; children weighing 15-30 kg, 1 time a day, 1/2 tablet each time, or as directed by a doctor. Children weighing more than 30 kg, the same as adults. Preventive treatment of immunodeficient patients: Adults: 2 tablets (400 mg) per day. Children: 4-8 mg per kilogram of body weight per day.

Some patients experience gastrointestinal discomfort, nausea, headache, dizziness, photophobia, paresthesia, and thrombocytopenia. Drug rash, itching, and hair loss are occasionally seen, and a few patients have reported allergic reactions. Liver damage may occur in a very small number of patients (mostly with idiosyncratic constitutions). This reaction often occurs in patients with a history of liver disease or drug sensitivity, and generally recovers after timely discontinuation of the drug. When the therapeutic dose exceeds the recommended daily 200 mg or 400 mg, reversible gynecomastia and lack of semen may occur in rare cases. When taken at a dose of 200 mg once a day, there are occasional reports of hair loss, and a temporary decrease in plasma testosterone concentration may also occur, but the plasma testosterone concentration will return to normal within 24 hours after taking the drug. When this dose is used for long-term treatment, the amount of testosterone is not much different from that of the control group.

This product is contraindicated in patients with acute or chronic liver disease or patients with known allergy to this product.

Precautions for children: There is limited information on the use of this product in children weighing less than 15kg, so it is not recommended for children. Precautions for pregnancy and lactation: Pregnant women have limited experience with the use of this product. Animal studies have shown that this product is reproductively toxic. The potential risks of human use are unknown. Therefore, this product should not be used during pregnancy unless the potential benefit to the mother outweighs the potential risk to the fetus. This product can be excreted in breast milk during lactation, so lactating women should stop breastfeeding when taking this product. Precautions for the elderly: Use with caution in elderly patients.

1 When alcohol and hepatotoxic drugs are used together with this product, the chance of hepatotoxicity increases. 2 When this product is used together with anticoagulants such as warfarin, coumarin, and indandione derivatives, their effects can be enhanced, resulting in a prolonged prothrombin time. Patients should be closely observed, prothrombin time should be monitored, and the dose of anticoagulants should be adjusted. 3 When cyclosporine is used together with this product, the blood concentration of the former will increase, and the risk of nephrotoxicity may increase. When the two drugs are used together, the blood concentration of cyclosporine should be monitored. 4 When antacids, anticholinergics, antispasmodics, histamine H2 receptor blockers, omeprazole, sucralfate, etc. are used together, the absorption of this product can be significantly reduced. Therefore, such drugs should be used 2 hours after taking this product. 5 When rifampicin is taken together with this product, the former will reduce the blood concentration of the latter and increase liver toxicity. Therefore, the two drugs should not be taken at the same time. When used together with isoniazid, the blood concentration of this product can be reduced, so it should be used with caution. 6 When phenytoin is used in combination with azoles, the metabolism of phenytoin can be slowed down, resulting in an increase in the blood concentration of phenytoin and a decrease in the blood concentration of azoles. 7 This product is contraindicated when used in combination with cisapride, astemizole, and terfenadine, because it inhibits the cytochrome P-450 metabolic channel and can cause heart rhythm disorders. 8 The buffer contained in didanosine (DDI) can increase the pH of the digestive tract and affect the absorption of this product. It must be used in combination with an interval of more than 2 hours. 9 This product has an antagonistic effect with amphotericin B, and its efficacy is weakened when used in combination.

Store in a dry place at 15-30℃ and out of reach of children.

0.2g*10s

36 months