Nimustine Hydrochloride for Injection

1 Anti-tumor effect: (1) It shows high anti-tumor activity against mouse leukemia L-1210. (2) It has a wide anti-tumor spectrum against mouse transplanted tumors. It shows excellent effects on lymphocytic leukemia L1210, granulocytic leukemia C-1498, plasmacytoma X-5563 (ascites type), Ehrlich's ascites carcinoma, and dural sarcoma MS-147. (3) This agent has a life-extending effect on mice with lymphocytic leukemia L1210 and methylcholanthrene-induced malignant glioma cells transplanted into the brain. 2 Mechanism of action: The main mechanism of action is to alkylate the DNA in the cell and reduce the molecular weight of the DNA, thereby inhibiting DNA synthesis.

Nimustine hydrochloride.

Relieve the subjective symptoms and signs of the following diseases: brain and neck cancer, brain tumors, lung cancer, digestive tract cancer (gastric cancer, colon/rectum cancer, esophageal cancer), malignant lymphoma and leukemia, etc.

Common dosage: 2-3 mg/kg body weight/time, dissolved in water for injection (5 mg/ml), intravenous injection. Then stop the drug for 4-6 weeks according to the peripheral blood picture, or 2 mg/kg body weight/time, intravenous administration, give it once every week, and then stop the drug for 4-6 weeks according to the peripheral blood picture after 2-3 weeks. This product should be used immediately after being prepared into solution.

Symptoms such as leukopenia, thrombocytopenia, anemia, bleeding tendency, allergies, loss of appetite, nausea, fatigue, fever, headache, hair loss and hypoproteinemia may be seen, and occasionally the liver and kidney functions may be slightly affected and interstitial pneumonia may occur.

The following patients should use the drug with caution: 1. Patients with impaired liver function. 2. Patients with impaired kidney function. 3. Patients with concurrent infection. 4. Patients with water beans (sometimes with fatal systemic disorders). Side effects: See relevant medical information for details.

When used in combination with other anti-tumor drugs or radioactive rays, bone marrow suppression may sometimes be aggravated.

Store in a cool, dark place away from light.

25mg

Yangtze River Pharmaceutical (Group) Co., Ltd.

• Founded in:

  2001-03-27

• Address:

  No. 1, South Yangtze River Road, Taizhou

• Tax NO.:

  913212007286987632

• Registered Funds:

  133 million yuan

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